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Veterans with PTSD to test High-THC cannabis in landmark trial

NCT ID NCT07224698

First seen Nov 05, 2025 · Last updated Jun 19, 2026 · Updated 25 times

Summary

This Phase 2 study will test whether inhaling high-THC cannabis (18-22% THC) can reduce PTSD symptoms in 320 U.S. veterans compared to a placebo with less than 1% THC. Participants will be randomly assigned to one of two groups in a double-blind design, and researchers will measure changes in PTSD severity and daily functioning over time. The goal is to provide reliable evidence on a treatment already widely used by veterans.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Scottsdale Research Institute

    Cave Creek, Arizona, 85331, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

high-THC cannabis (dried flower with 18-22% THC)

What this could lead to

If it works, this could provide a controlled, evidence-based option for veterans to manage PTSD symptoms using inhaled cannabis.

What could go wrong

This is a Phase 2 trial, so results are still early. The placebo effect is strong in PTSD studies, and high-THC cannabis may cause side effects like anxiety or impaired cognition.

Conditions

The condition(s) this trial relates to.

cannabis dependence combat disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.