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Can a common heart drug stop PTSD before it starts?

NCT ID NCT07452978

Prevention Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether the blood pressure medication propranolol can prevent post-traumatic stress disorder (PTSD) in women who have experienced sexual violence. 34 women will receive either propranolol or a placebo within 72 hours of the assault, then take it for about three weeks. Researchers will check for PTSD symptoms five weeks later to see if the drug helps reduce traumatic memories.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Propranolol
What this could lead to
If it works, this could point toward a simple, short-term medication to prevent PTSD after trauma.
What could go wrong
This is a very small, early pilot study with only 34 participants. The drug may not reduce PTSD risk, and side effects like low blood pressure or fatigue are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * female, cisgender * \>= 18 years * The patient agrees to comply with the contraception requirements detailed in the protocol. * SBP \> 10 cmHg * Heart rate \>= 55 bpm * Received for consultation regarding sexual violence at the Medical-Legal Unit (UMJ) for sexual assault and/or rape within 72 hours of the incident occurring. * Affiliated with a social security system * Patient who understands and reads french * Free, informed, and written consent signed by the participant Exclusion Criteria: * Protected adult (guardianship, curatorship, judicial protection) * Repeated or chronic sexual violence * Impaired consciousness or alertness, amnesia regarding events * Known hypersensitivity to propranolol or treated asthma, even if only occasional * Known interactions with Propranolol (combinations not recommended and combinations to be used with caution) indicated in the summary of product characteristics * Patients who have suffered head trauma within the last year or who have clinical symptoms and neurological sequelae * Patient with myasthenia gravis, with a personal history of psoriasis * Patient wearing contact lenses * Patient with severe liver disease and/or significant renal impairment * Current use of a beta-blocker, regardless of dosage form. * Current use of a drug that has a contraindicated or inadvisable drug interaction with propranolol: bepridil, diltiazem, verapamil, fingolimod. * Addiction: presence of a current disorder related to the use of psychoactive substances. * Current treatment with benzodiazepines * Individuals currently receiving psychotropic treatment such as antipsychotics or antidepressants. * People with known current or past serious psychiatric disorders. * High suicide risk, i.e., participants who responded positively to items 4 or 5 of the C-SSRS suicidal ideation scale or any positive assessment of suicidal behavior in the 6 months prior to selection. * Patients who have previously been diagnosed with PTSD. * Pregnant or breastfeeding women.

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Conditions

The condition(s) this trial relates to.

combat disorder post-traumatic stress disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PTSD - post traumatic stress disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.