Cocaine dependence

This study tests whether tirzepatide, a drug approved for weight management, can help people who are obese and have a moderate to severe stimulant use disorder (like methamphetamine or cocaine). Participants receive weekly injections for 20 weeks, along with counseling and brain …

This early-stage study tests a gene therapy given through an IV for adults with cocaine use disorder who are in remission. The therapy helps the body produce an enzyme that breaks down cocaine quickly, reducing the drug's pleasurable effects. The main goal is to check safety, wit…

This study tests whether a smartphone app can help people who are already on methadone treatment cut down on opioid and cocaine use. The app asks participants to take random drug tests at home and rewards them with money for negative results. Researchers want to see if app users …

This pilot study tests a web-based program called LDART for adults with stimulant use disorder (cocaine or methamphetamine). The program includes daily goal setting, motivational messages from people in recovery, and links to support groups. Researchers want to see if it's feasib…

This study aimed to test whether exenatide (Bydureon), a drug approved for type 2 diabetes, could safely reduce the urge to use cocaine. Researchers planned to give the drug or a placebo to people with cocaine use disorder and measure how many cocaine doses they chose to take. Ho…

Researchers are testing whether semaglutide, a drug used for diabetes and weight loss, is safe and tolerable in adults with cocaine use disorder. The trial includes 40 people who use cocaine often, some of whom also have HIV. Participants receive weekly injections of semaglutide …

This study looks at whether a single 25 mg dose of psilocybin (the active ingredient in magic mushrooms) can be safely given to people with cocaine use disorder who want to quit. Ten adults from Los Angeles will take the drug in a comfortable room with two clinicians present, and…

This study adapts a proven PTSD therapy (STAIR-NT) for people in methadone treatment who also use cocaine and opioids. Researchers will test if the adapted program is practical and acceptable, and whether it reduces substance use and PTSD symptoms. About 80 participants will be r…

This study tests whether methylphenidate (Ritalin) can help weaken memories that link drug cues to cocaine use. Fifty-one adults with cocaine use disorder will receive either methylphenidate or a placebo before recalling drug-related memories, while brain activity and skin respon…

This study uses PET scans with a special tracer to measure brain synapse density in 80 people—some with cocaine use disorder and some healthy controls. Researchers aim to see if cocaine changes brain connections, especially in areas linked to decision-making and addiction. Partic…

This study tests a new imaging tracer called [18F]fluortriopride to see if it can clearly show D3 dopamine receptors in the brain. Researchers will compare brain scans from healthy volunteers and people with cocaine dependence, and also check how consistent the tracer's signals a…

This study was designed to test whether a drug called lorcaserin could help people with cocaine dependence by rebalancing serotonin in the brain. Researchers planned to use brain scans to see if the drug reduced cravings and impulsivity. However, the study was withdrawn before en…

This study aimed to see if a brain training method called ZQLN could improve brain activity and thinking skills in people with cocaine use disorder. It planned to enroll adults aged 21 to 51 who had completed detox. However, the study was withdrawn before any participants were en…