Chronic apical periodontitis

This study tests whether a special irrigation solution called nanochitosan can help regenerate damaged tissue in infected teeth. Sixty adults with dead teeth and chronic infection will receive one of three irrigation methods during a single dental visit. Researchers will check fo…

This study tests whether using a donor bone graft (allograft) works as well as using your own bone (autograft) to repair defects where a tooth infection has damaged the surrounding bone. Fifty adults with these defects will receive one of the two grafts along with a collagen memb…

This study tests whether a gel made from a patient's own blood (platelet-rich fibrin) can help regenerate the inner part of infected or dead teeth in adults. 57 participants will receive either the gel or a standard blood-clot treatment. The goal is to see if the gel reduces infe…

This trial tests whether flushing the inside of a tooth with cold saline (about 2.5°C) after root canal retreatment can lower pain and inflammation. One hundred adults needing retreatment on a lower premolar will be randomly assigned to receive either cold or room-temperature sal…

This trial looks at whether changing how the dentist's tool moves during a root canal can reduce pain afterward. Adults with an infected lower premolar will get standard root canal treatment, but the file system will use either a continuous spin or a back-and-forth motion, with d…

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation and infection. Researchers will measure certain proteins in the fluid around the tooth root before and after treatment.

This study will check if certain gene variations (MMP-2 and MMP-3) are linked to how well the bone around a tooth heals after root canal treatment. Fifty adults with chronic tooth infections will get standard root canal therapy and be followed for 12 months. Researchers will comp…