Could a Nano-Irrigation save dead teeth?
NCT ID NCT07584928
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a special irrigation solution called nanochitosan can help regenerate damaged tissue in infected teeth. Sixty adults with dead teeth and chronic infection will receive one of three irrigation methods during a single dental visit. Researchers will check for healing using sensitivity tests, X-rays, and pain reports over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nanochitosan
- What this could lead to
- If it works, this could offer a way to heal infected teeth naturally, possibly avoiding root canals or tooth loss.
- What could go wrong
- This is a small, early-stage trial with only 60 people, so results may not apply widely. The treatment may not work better than standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: -adult patients in the age range 18-40 years with necrotic mature anterior teeth with chronic apical periodontitis as evidenced by apical radiolucency. * patients with good general health, without known systemic diseases or allergic reactions to any of the material used affecting healing outcome, with no sex predilection Exclusion Criteria: * medically compromised patients, systemic conditions e.g. uncontrolled diabetes or those on immunosuppressive drugs. * pregnant females * patients with generalized chronic periodontitis, mobility, and deep pockets * non-restorable teeth or teeth with open apices * teeth where post is needed to be restored or with previous root canal therapy * teeth with developmental anomalies, external and internal resorption
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Suez Canal University
Ismailia, Egypt