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Gene study could predict root canal healing

NCT ID NCT07529964

Knowledge-focused Sponsor: TC Erciyes University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will check if certain gene variations (MMP-2 and MMP-3) are linked to how well the bone around a tooth heals after root canal treatment. Fifty adults with chronic tooth infections will get standard root canal therapy and be followed for 12 months. Researchers will compare healing in people with different gene types to see if genetics play a role.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help dentists predict which patients might heal better after root canal treatment based on their genes.
What could go wrong
This is a small, early-stage study (50 people) that only looks at genetic links, not a treatment. It may not find a clear connection or change how care is given.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adult patients aged 18-65 years diagnosed with chronic apical periodontitis in single-rooted teeth and requiring primary nonsurgical root canal treatment. All participants will be classified as ASA I or II and will be recruited from patients referred to the Department of Endodontics. Only individuals meeting the predefined inclusion and exclusion criteria will be enrolled. Participants will undergo standardized treatment and follow-up under controlled clinical conditions.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Single-rooted teeth * PAI score ≥ 3 * Fully developed root apices * Periodontal probing depth less than 5 mm * Indication for primary nonsurgical root canal treatment Exclusion Criteria: * Previous endodontic treatment in the selected tooth * Diagnosis of symptomatic apical abscess * Presence of root fracture or internal/external resorption * Use of systemic antibiotics within the previous 4 weeks * Analgesic intake within 48 hours before treatment * Ongoing immunosuppressive therapy * Pregnancy or breastfeeding

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic apical periodontitis Periapical healing

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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