Central nervous system disorder
MONDO:0002602A disease involving the central nervous system.
Also known as: CNS disorder, central nervous disease, central nervous system disease, central nervous system disease or disorder, central nervous system disorder, disease of central nervous system, disease of the central nervous system, disease or disorder of central nervous system
20397 clinical trials for this condition and its sub-types, 119 tagged with Central nervous system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system disorder
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Brain disorder 136 trials · 16,663 incl. sub-types
71 sub-types
- Mental disorder 249 trials · 7,372 incl. sub-types Sub-types →
- Cerebrovascular disorder 107 trials · 3,282 incl. sub-types Sub-types →
- Basal ganglia disorder 9 trials · 1,318 incl. sub-types Sub-types →
- Brain neoplasm 246 trials · 1,077 incl. sub-types Sub-types →
- Multiple sclerosis 765 trials · 852 incl. sub-types Sub-types →
- Insomnia 822 trials · 826 incl. sub-types Sub-types →
- Cerebral cortex disorder 0 trials · 721 incl. sub-types Sub-types →
- Brain injury 220 trials · 692 incl. sub-types Sub-types →
- Epilepsy 461 trials · 645 incl. sub-types Sub-types →
- Migraine disorder 390 trials · 411 incl. sub-types Sub-types →
- Cerebellar disorder 9 trials · 270 incl. sub-types Sub-types →
- Visual pathway disorder 1 trial · 201 incl. sub-types Sub-types →
- Pituitary gland disorder 18 trials · 175 incl. sub-types Sub-types →
- Thalamic disorder 0 trials · 110 incl. sub-types Sub-types →
- Intracranial hypertension 51 trials · 97 incl. sub-types Sub-types →
- Encephalitis 25 trials · 95 incl. sub-types Sub-types →
- Hydrocephalus 52 trials · 78 incl. sub-types Sub-types →
- Cerebral degeneration 0 trials · 61 incl. sub-types Sub-types →
- Hepatic encephalopathy 44 trials Sub-types →
- Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types Sub-types →
- Cerebral lipidosis with dementia 0 trials · 38 incl. sub-types Sub-types →
- Intracranial hypotension 32 trials
- Cluster headache syndrome 26 trials Sub-types →
- Brain edema 23 trials
- Narcolepsy without cataplexy 22 trials
- Encephalomalacia 1 trial · 13 incl. sub-types Sub-types →
- Olfactory nerve disorder 8 trials · 12 incl. sub-types Sub-types →
- Prion disease 5 trials · 11 incl. sub-types Sub-types →
- Traumatic encephalopathy 11 trials
- Cerebral cortical dysplasia 2 trials · 7 incl. sub-types Sub-types →
- Progressive bulbar palsy 5 trials Sub-types →
- Akinetic mutism 3 trials
- Bilirubin encephalopathy 3 trials Sub-types →
- Central nervous system cyst 3 trials Sub-types →
- Encephaloclastic disorder 0 trials · 3 incl. sub-types Sub-types →
- Encephalopathy, acute, infection-induced 2 trials · 3 incl. sub-types Sub-types →
- Megalencephaly 3 trials Sub-types →
- Cerebral malaria 2 trials
- Leukoencephalopathy, megalencephalic 0 trials · 2 incl. sub-types Sub-types →
- Wernicke encephalopathy 1 trial
- Brain compression 1 trial
- Carbon monoxide-induced delayed encephalopathy 1 trial
- Cerebral sarcoidosis 1 trial
- Reye syndrome 0 trials
- XK aprosencephaly 0 trials
- Acute bilirubin encephalopathy 0 trials
- Aprosencephaly 0 trials
- Atelencephaly 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autosomal recessive frontotemporal pachygyria 0 trials
- Brain malformations with or without urinary tract defects 0 trials
- Bulbar polio 0 trials
- Central nervous system origin vertigo 0 trials
- Cerebritis 0 trials
- Chronic bilirubin encephalopathy 0 trials
- Colpocephaly 0 trials
- Complex cortical dysplasia with other brain malformations 0 trials Sub-types →
- Corpus callosum agenesis of blepharophimosis robin type 0 trials
- Corpus callosum dysgenesis X-linked recessive 0 trials
- Corpus callosum dysgenesis cleft spasm 0 trials
- Corpus callosum dysgenesis hypopituitarism 0 trials
- Diabetic encephalopathy 0 trials
- Disorder of optic chiasm 0 trials
- Encephalopathy due to mitochondrial and peroxisomal fission defect 0 trials Sub-types →
- Encephalopathy, acute transient 0 trials
- Encephalopathy, recurrent, of childhood 0 trials
- Glycine encephalopathy 0 trials Sub-types →
- Hypothalamic hamartomas with gelastic seizures 0 trials
- Meningoencephalocele 0 trials
- Midbrain disorder 0 trials
- Occipital pachygyria and polymicrogyria 0 trials
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Neurodegenerative disease 186 trials · 3,277 incl. sub-types
22 sub-types
- Tauopathy 24 trials · 1,190 incl. sub-types Sub-types →
- Demyelinating disease 27 trials · 931 incl. sub-types Sub-types →
- Inherited neurodegenerative disorder 10 trials · 807 incl. sub-types Sub-types →
- Motor neuron disorder 69 trials · 506 incl. sub-types Sub-types →
- Synucleinopathy 18 trials · 237 incl. sub-types Sub-types →
- Cerebellar degeneration 6 trials · 150 incl. sub-types Sub-types →
- Primary progressive aphasia 42 trials · 71 incl. sub-types Sub-types →
- Cerebral degeneration 0 trials · 61 incl. sub-types Sub-types →
- Neuroaxonal dystrophy 1 trial · 9 incl. sub-types Sub-types →
- Secondary Parkinson disease 9 trials Sub-types →
- Primary progressive apraxia of speech 2 trials
- Marchiafava-Bignami disease 1 trial
- Human prion disease 1 trial Sub-types →
- Brachial amyotrophic diplegia 0 trials
- Choroidal sclerosis 0 trials Sub-types →
- Eyelid degenerative disorder 0 trials
- Hypertrophic olivary degeneration 0 trials
- Infantile bilateral striatal necrosis 0 trials Sub-types →
- Olivopontocerebellar atrophy 0 trials
- Primary progressive freezing gait 0 trials
- Senile degeneration of brain 0 trials
- Superficial siderosis 0 trials
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Central nervous system neoplasm 51 trials · 1,979 incl. sub-types
10 sub-types
- Central nervous system cancer 130 trials · 1,699 incl. sub-types Sub-types →
- Brain neoplasm 246 trials · 1,077 incl. sub-types Sub-types →
- Tumor of meninges 1 trial · 123 incl. sub-types Sub-types →
- Central nervous system hematopoietic neoplasm 0 trials · 107 incl. sub-types Sub-types →
- Spinal cord neoplasm 36 trials · 77 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Central nervous system organ benign neoplasm 1 trial · 57 incl. sub-types Sub-types →
- Central nervous system germ cell tumor 6 trials · 9 incl. sub-types Sub-types →
- Epidural abscess 5 trials
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
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Spinal cord disorder 46 trials · 1,251 incl. sub-types
10 sub-types
- Spinal cord injury 650 trials
- Anterior horn disorder 0 trials · 481 incl. sub-types Sub-types →
- Spinal cord neoplasm 36 trials · 77 incl. sub-types Sub-types →
- Spina bifida 44 trials · 59 incl. sub-types Sub-types →
- Myelitis 4 trials · 52 incl. sub-types Sub-types →
- Syringomyelia 6 trials Sub-types →
- Tethered spinal cord syndrome 6 trials
- Radiation myelitis 0 trials
- Segmental spinal dysgenesis 0 trials
- Vascular myelopathy 0 trials
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Autoimmune disorder of central nervous system 2 trials · 874 incl. sub-types
8 sub-types
- Multiple sclerosis 765 trials · 852 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Central nervous system lupus 2 trials
- Autoimmune epilepsy 1 trial
- Miller Fisher syndrome 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autoimmune optic neuritis 0 trials
- Primary hypophysitis 0 trials Sub-types →
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Palsy 36 trials · 843 incl. sub-types
10 sub-types
- Cerebral palsy 441 trials · 497 incl. sub-types Sub-types →
- Hemiplegia 175 trials · 178 incl. sub-types Sub-types →
- Quadriplegia 73 trials
- Paraplegia 47 trials · 68 incl. sub-types Sub-types →
- Facial paralysis 19 trials · 34 incl. sub-types Sub-types →
- Respiratory paralysis 20 trials
- Erb palsy 11 trials
- Ophthalmoplegia 0 trials · 11 incl. sub-types Sub-types →
- Progressive bulbar palsy 5 trials Sub-types →
- Klumpke's paralysis 0 trials
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Encephalomyelitis 3 trials · 226 incl. sub-types
7 sub-types
- Encephalitis 25 trials · 95 incl. sub-types Sub-types →
- Meningitis 42 trials · 73 incl. sub-types Sub-types →
- Myelitis 4 trials · 52 incl. sub-types Sub-types →
- Optic neuritis 21 trials · 25 incl. sub-types Sub-types →
- Hypophysitis 2 trials Sub-types →
- Venezuelan equine encephalitis 1 trial
- Cerebritis 0 trials
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Autonomic nervous system disorder 59 trials · 209 incl. sub-types
13 sub-types
- Dysautonomia 16 trials · 64 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Sympathetic nervous system disorder 8 trials · 28 incl. sub-types Sub-types →
- Pure autonomic failure 18 trials
- Autonomic dysreflexia 11 trials
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease 5 trials
- Baroreflex failure 1 trial
- Frey syndrome 0 trials
- Chronic hiccup 0 trials
- Harlequin syndrome 0 trials
- Idiopathic peripheral autonomic neuropathy 0 trials
- Parasympathetic nervous system disorder 0 trials Sub-types →
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Central nervous system infectious disorder 10 trials · 163 incl. sub-types
12 sub-types
- Viral infection of central nervous system 3 trials · 58 incl. sub-types Sub-types →
- Infectious encephalitis 3 trials · 50 incl. sub-types Sub-types →
- Infectious meningitis 3 trials · 49 incl. sub-types Sub-types →
- Prion disease 5 trials · 11 incl. sub-types Sub-types →
- Central nervous system tuberculosis 1 trial · 7 incl. sub-types Sub-types →
- Epidural abscess 5 trials
- Intracranial abscess 3 trials
- Cerebral malaria 2 trials
- Congenital toxoplasmosis 2 trials
- Human prion disease 1 trial Sub-types →
- Subdural empyema 1 trial
- Neuroschistosomiasis 0 trials
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Optic nerve disorder 23 trials · 95 incl. sub-types
8 sub-types
- Optic atrophy 4 trials · 26 incl. sub-types Sub-types →
- Optic neuritis 21 trials · 25 incl. sub-types Sub-types →
- Low tension glaucoma 21 trials
- Anterior ischemic optic neuropathy 8 trials · 10 incl. sub-types Sub-types →
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Optic disk drusen 1 trial
- Extensive peripapillary myelinated nerve fibers 0 trials
- Isolated optic nerve aplasia 0 trials
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Tinnitus 90 trials
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Central nervous system vasculitis 3 trials · 55 incl. sub-types
5 sub-types
- Temporal arteritis 52 trials Sub-types →
- Primary central nervous system vasculitis 2 trials Sub-types →
- Benign angiitis of the central nervous system 0 trials
- Central nervous system AIDS arteritis 0 trials
- Cerebral arteritis 0 trials
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Trigeminal neuralgia 37 trials
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Cerebrospinal fluid leak 16 trials · 17 incl. sub-types
1 sub-type
- Cerebrospinal fluid rhinorrhea 2 trials
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High pressure neurological syndrome 0 trials · 5 incl. sub-types
1 sub-type
- Decompression sickness 5 trials
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SPAST-related motor disorder 0 trials · 2 incl. sub-types
1 sub-type
- Hereditary spastic paraplegia 4 2 trials
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1 sub-type
- NDE1-related microhydranencephaly 0 trials
Most studied deeper sub-types
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Experimental Alzheimer's drug aims to lower brain 'Tangles' in Early-Stage patients
Disease control OngoingThis early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…
Phase 1 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Free drug access for Parkinson's patients with specific gene mutation
Disease control Expanded access (ended)This program offers continued free access to the experimental drug BIA 28-6156 for people with Parkinson's disease who have a specific change in the GBA1 gene and have already completed the ACTIVATE study. Participants take one 60mg pill daily. The goal is to provide ongoing trea…
Sponsor: Bial R&D Investments, S.A. • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Can a dopamine-blocking drug safely control tourette syndrome over years?
Disease control OngoingThis trial investigates the long-term safety of ecopipam, a drug that blocks dopamine D1 and D5 receptors, in children, adolescents, and adults with Tourette syndrome. Participants who completed a prior study may enroll and receive ecopipam for up to 24 weeks or longer. The main …
Phase 3 • Sponsor: Emalex Biosciences Inc. • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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Could a new drug slow Alzheimer's? large trial underway
Disease control OngoingThis phase 3 study tests whether donanemab, an antibody given through an IV, can safely slow cognitive decline in 1500 people with early Alzheimer's. Participants receive either the drug or a placebo for up to 93 weeks. The main goal is to measure changes in thinking and daily fu…
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Magnetic brain zaps may restore movement after stroke
Disease control By invitation onlyThis study tests a new non-invasive brain stimulation device called kTMP (kilohertz transcranial magnetic perturbation) to see if it can help improve arm and hand movement in people who have had a stroke. The trial involves 7 adults aged 18-80 who had a stroke at least 12 months …
Sponsor: Magnetic Tides • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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New dosing strategy aims to make Alzheimer's drug safer and more effective
Disease control OngoingThis study tests different dosing schedules of the drug donanemab in about 1,175 people with early symptomatic Alzheimer's disease. The goal is to find a regimen that lowers brain amyloid plaques while reducing the risk of a side effect called ARIA-E (brain swelling or small blee…
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New pill aims to slow Parkinson's in patients with genetic mutation
Disease control OngoingThis study tests an experimental drug called BIA 28-6156 in people with Parkinson's disease who have a specific change in the GBA1 gene. The goal is to see if the drug can delay the worsening of movement-related daily living skills over 78 weeks. About 237 participants will recei…
Phase 2 • Sponsor: Bial R&D Investments, S.A. • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Brain injection aims to slow Huntington's
Disease control OngoingThis early-stage study tests a gene therapy called AB-1001 in 5 adults with early Huntington's disease. The treatment is injected directly into the brain to potentially slow the disease. The main goal is to check safety, but researchers will also look at brain changes on MRI and …
Phase 1/2 • Sponsor: AskBio France, SAS, a subsidiary of AskBio Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Gene therapy boost for krabbe patients after transplant
Disease control OngoingThis early-phase trial tests a single infusion of a gene therapy called FBX-101 in 9 people with Krabbe disease who have already received a stem cell transplant. The therapy uses a harmless virus to deliver a working copy of the GALC gene, aiming to improve motor function and saf…
Phase 1/2 • Sponsor: Forge Biologics, Inc • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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AI boosts brain scan accuracy in massive new trial
Diagnosis By invitation onlyThis study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…
Sponsor: Yaou Liu • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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AI takes on radiologists: 30,000-Patient trial to see who reads brain scans better
Diagnosis By invitation onlyThis study compares how well AI and radiologists diagnose brain diseases using CT and MRI scans. Over 30,000 patients will be included, and the AI has been trained on more than 100,000 previous scans. The goal is to see if AI can match human experts and whether combining AI with …
Sponsor: Yaou Liu • Aim: Diagnosis
Last updated Jun 26, 2026 16:35 UTC
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New hope for Alzheimer's psychosis: Long-Term drug trial underway
Symptom relief By invitation onlyThis study is testing the long-term safety of a drug called ML007C-MA for people with Alzheimer's disease who also have hallucinations and delusions. About 210 adults who completed a previous study will take the drug twice daily for up to 52 weeks. The goal is to see if the drug …
Phase 2 • Sponsor: MapLight Therapeutics • Aim: Symptom relief
Last updated Aug 09, 2026 00:00 UTC
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Could a pill help restore speech in progressive aphasia?
Symptom relief OngoingThis study tests a drug called neflamapimod in 20 people with a language disorder called nonfluent variant primary progressive aphasia (nfvPPA). The goal is to see if the drug is safe and if it can improve language symptoms. Participants will receive either the drug or a placebo …
Phase 2 • Sponsor: EIP Pharma Inc • Aim: Symptom relief
Last updated Jul 08, 2026 00:00 UTC
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Sound waves for sharper minds: ultrasound trial targets sleep and memory in Alzheimer's risk
Symptom relief By invitation onlyThis study tests a new, non-invasive treatment using low-intensity ultrasound to stimulate a deep brain area (the hippocampus) in older adults with mild memory and sleep problems. The goal is to see if it safely improves sleep quality and thinking skills. Twenty participants aged…
Sponsor: Chinese University of Hong Kong • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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What happens years after a stroke? finland asks 2,000 survivors
Knowledge-focused By invitation onlyResearchers in Finland are surveying about 2,000 adults who were treated for a stroke between 2020 and 2022 in two regions. The postal questionnaire asks about health, daily functioning, work and income, social inclusion, and experiences with social and health services. The goal …
Sponsor: The Finnish Association of People with Physical Disabilities • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Can a blood marker tell fever from infection in stroke?
Knowledge-focused CancelledThis study follows adults hospitalized with hemorrhagic stroke to see how procalcitonin, a blood marker, changes over the first few days. The goal is to determine if procalcitonin can help doctors tell whether a fever is due to a bacterial infection or another cause, potentially …
Sponsor: CAMC Health System • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
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Radioactive tracer reveals tau tangles in Alzheimer's brains
Knowledge-focused By invitation onlyThis study tests a new radioactive compound called F 18 T807 that lights up tau tangles in the brain during a PET scan. Researchers want to see if the amount of tau relates to memory and thinking problems in people with a rare, inherited form of Alzheimer's disease. About 130 adu…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Meditation brain study in Parkinson's withdrawn before starting
Knowledge-focused CancelledThis study planned to use brain scans to measure how a meditation technique called OM affects dopamine and stress markers in people with Parkinson's disease. It was withdrawn before enrolling any participants, so no results are available. The goal was to better understand meditat…
Phase 2 • Sponsor: Andrew Newberg • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:00 UTC