Bronchitis

This phase 2 trial tested whether infusions of PROCHYMAL, a stem cell product, are safe and can help people with moderate to severe COPD. 62 participants received either stem cells or a placebo. The main goal was to check for side effects, and researchers also looked at changes i…

This study looked at how well the antibiotic Klacid SR works for adults with respiratory infections like bronchitis and mild pneumonia, especially in those who had taken it before. Over 3,000 participants were treated in regular doctor visits, and doctors checked if symptoms impr…

This phase 3 trial tested mepolizumab, a drug that targets eosinophils (a type of white blood cell), in 18 COPD patients with eosinophilic bronchitis. The goal was to see if it reduces eosinophil levels in the airways and lowers the risk of severe flare-ups. Participants received…

This study tested two medications, roflumilast and azithromycin, in over 1,000 people with severe COPD and chronic bronchitis. The goal was to see which drug better prevents hospitalizations or death. Participants were current or former smokers aged 40 or older who had been hospi…

This trial tests a device called RheOx that delivers controlled heat pulses to the airways to reduce excess mucus-producing cells, which are a hallmark of chronic bronchitis. The study enrolls adults aged 35 to 80 with moderate-to-severe COPD and chronic bronchitis symptoms. Part…

This trial tests whether a continuous infusion of the local anesthetic ropivacaine, delivered through small catheters placed near the breastbone, can improve recovery after cardiac surgery. The study focuses on patients at higher risk of respiratory complications, such as older a…

This study tests whether a device called oscillatory positive expiratory pressure (OPEP) therapy can reduce cough symptoms and improve lung mechanics in people with COPD. Participants use the device at home twice daily for four weeks. Researchers compare lung function and symptom…

This study tested how well the over-the-counter medication Mucinex works for people with stable chronic bronchitis when used over 12 weeks. 82 adults aged 40 and older took part, tracking their symptoms, satisfaction, and any side effects. The goal was to see if long-term use hel…

This study tested whether a supplement called GCWB1001 can help adults with mild breathing symptoms like cough, phlegm, and chest tightness. 120 people took either the supplement or a placebo for 12 weeks. The goal was to see if symptoms improved and if it was safe.

This Phase 3 trial tested a new drug called YHP2401 against two other drugs for acute bronchitis. 286 adults with cough and phlegm took one of the treatments for 7 days. The goal was to see if YHP2401 works better at reducing symptoms.

This study looked at 200 children aged 2 to 12 with mild to moderate croup, a viral infection that causes a barking cough and breathing trouble. Researchers compared giving the steroid dexamethasone as a pill versus an injection to see which works better for easing symptoms. The …

This study tested two different spacer devices (valved holding chambers) used to give asthma medicine to children aged 6 months to 4 years with sudden wheezing. 80 children from Finnish hospitals took part. The goal was to see if one spacer worked better for symptom relief, hospi…

This study tested whether a herbal extract called Pelargonium sidoides (EPs®7630) helps adults with acute bronchitis recover faster and need fewer antibiotics. Over 300 participants in Switzerland were randomly assigned to receive the extract or usual care. The main goal was to s…

This completed Phase 2 trial tested whether the experimental drug ALC-2203 can reduce symptoms of acute bronchitis, like cough and chest pain. 169 adults with moderate to severe symptoms took either ALC-2203, an active comparator, or a placebo for 7 days. Researchers measured cha…

This study tested whether a 25% lower dose of dexamethasone (0.15 mg/kg) works as well as the standard dose (0.6 mg/kg) for treating croup in children. Croup is a viral infection that causes airway swelling and breathing trouble. The trial involved 50 children and tracked return …

This phase 3 trial tested whether the drug N-acetylcysteine (NAC) can thin mucus and make it easier to cough up in adults with respiratory infections like bronchitis or bronchiectasis. About 333 hospitalized patients in China received either NAC, another expectorant (ambroxol), o…

This early-stage trial tests two experimental drugs, AG2203L and AG2203E, in healthy adults to see if they are safe when taken together and whether they affect each other. Participants receive each drug alone and then both together in a random order. The goal is to measure how th…

This completed study analyzed over 230,000 adults in France who had lower respiratory tract infections like pneumonia, bronchitis, or flu. Researchers used anonymous electronic health records from 2015 to 2024 to describe patient characteristics, how often antibiotics were prescr…

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…