Breast carcinoma in situ

This trial tests whether a 3D imaging device, used during lumpectomy surgery, can help surgeons see and remove all cancerous tissue while the patient is still in the operating room. The goal is to reduce the chance of leaving cancer cells behind, which often leads to a second sur…

This trial studies whether breast-conserving surgery (lumpectomy) followed by radiation is a safe and effective option for women aged 40 and older who have two or more breast cancer tumors in the same breast. The goal is to see if this less invasive approach can control the cance…

This study tested a type of breast cancer surgery called nipple-sparing mastectomy, where the breast tissue is removed but the nipple and skin are kept. It involved 450 women with early-stage breast cancer who needed a full mastectomy. The goal was to see if this surgery keeps th…

This study tested whether a drug called ruxolitinib can reduce abnormal breast cells in people with high-risk or precancerous breast conditions like DCIS or atypical hyperplasia. Half of the 84 participants took ruxolitinib for about 15 days before surgery, and the other half too…

This phase II trial tested a 9-day course of whole breast radiation (hypofractionated radiotherapy) in 102 patients with early-stage breast cancer (stage 0-IIB). The goal was to see if a shorter treatment time could maintain effectiveness while reducing side effects. Researchers …

This study tested whether contrast-enhanced mammography (CEM) can find more breast cancers than standard mammography in women already diagnosed with breast cancer. 89 women received CEM, which uses an iodine dye to highlight suspicious areas. The goal was to see if CEM detects ad…

Researchers are testing whether low-dose tamoxifen or a 5:2 intermittent fasting diet can raise levels of a protein called sex hormone binding globulin (SHBG) in women at high risk of breast cancer. Higher SHBG levels have been linked to lower breast cancer risk. The trial enroll…

This study tested a silver-plated wound dressing (Silverlon) in 17 breast cancer patients receiving radiation therapy. The goal was to see if the dressing could reduce the severity of acute radiation dermatitis, a common skin reaction that causes redness, peeling, and pain. Patie…

This study tested whether using telehealth visits and smart pill bottles can help breast cancer patients take their hormone therapy as prescribed. 305 women and men with early-stage hormone receptor-positive breast cancer participated. They either had regular in-person checkups o…

This study looked at whether using a special numbing technique (tumescent local anesthesia) during breast cancer surgery leads to less pain afterward compared to standard general anesthesia. 349 women who had breast cancer surgery took part. The goal was to see if this approach c…

This study tested a special pain program for breast cancer survivors who have joint and muscle pain from taking aromatase inhibitors (hormone therapy). The program combined education, coping skills, and gentle movement to help reduce pain, improve mood, and make it easier to stic…

This study tested whether a nerve block using ropivacaine could reduce pain after breast cancer surgery compared to a placebo. 182 women having breast-conserving surgery with sentinel lymph node biopsy took part. The goal was to see if fewer patients needed strong painkillers in …

This study tested whether a newer nerve block called ESP works as well as the standard PVB block for pain after breast cancer surgery. 292 women received one of the two blocks before surgery. The main goal was to see how many needed morphine in the first two hours after surgery. …

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers want to understand how the cancer is found, what risk factors are involved, and how it is treated. The goal is to find ways to improve care and reduce …

This study tested a custom-made device called the Breast Cancer Locator (BCL) in 35 women with non-palpable breast cancer. The device helps surgeons see exactly where the tumor is during breast-conserving surgery, with the goal of removing all cancer in one go and reducing the ne…

This study looked at whether a special, graph-based genetic counseling method helps newly diagnosed breast cancer patients better understand their risk of cancer in the other breast and make more informed surgery choices. About 400 patients participated, comparing this new approa…

This completed study involved 775 women who had breast-conserving surgery and radiation for breast cancer. Researchers compared different surgery and radiation techniques to see which ones led to less breast hardening (fibrosis) and better cosmetic results. The goal was to find w…

This completed study tested a web-based decision aid called RealRisks in 70 high-risk women aged 35-74. The tool combines electronic health records and patient-reported data to calculate breast cancer risk and improve understanding of prevention options. Researchers measured whet…

This study collected information and samples from 105 breast cancer survivors and healthy volunteers to create a research database. The goal is to help doctors better diagnose cancer, predict long-term health, and develop future treatments. Participants provided blood, urine, and…

This study tested whether a high-resolution PET-CT scan of the removed tumor during breast-conserving surgery can help surgeons see if any cancer cells remain at the edges. About 206 women with early-stage breast cancer received a low-dose radioactive tracer before surgery. After…

This study looked at 228 women with ductal carcinoma in situ (DCIS) or micro-invasive DCIS who needed a mastectomy. Researchers wanted to see if doing a sentinel lymph node biopsy upfront could help avoid a more extensive axillary lymph node dissection later. The goal was to find…