Asthma

This trial tests whether a single 10-minute lesson from an artificially intelligent robot can improve inhaler technique and asthma control in children ages 4 to 11. Researchers will compare standard asthma education with the robot-led session, measuring inhaler skills, medication…

This study will follow 600 adults in Korea who have been prescribed Breztri for COPD, a long-term lung disease. Researchers want to see how safe the drug is in everyday use and whether it works as expected. Participants will take Breztri as their doctor prescribes, and the study …

Researchers are studying whether a structured care plan called the Indian Asthma Care Bundle (I-ACB) helps adults and children in India manage asthma after a severe attack. The study follows patients discharged from the hospital and compares those who receive the bundle with thos…

This pilot study tests a digital spacer device called aflo™ in children aged 6 to 18 with uncontrolled asthma. The device attaches to a standard inhaler and gives real-time feedback on technique, reminders, and tracks symptoms through a mobile app. Researchers want to see if usin…

This trial is testing an experimental drug called JNJ-95597528 in adults with moderate to severe asthma that is not well controlled by current treatments. The goal is to see if the drug can reduce the number of asthma attacks over 48 weeks compared to a placebo. Participants will…

This phase 2 trial tests whether daily ginger extract capsules can improve airway responsiveness and reduce inflammation in adults with asthma. Participants with mild to severe persistent asthma, despite using inhaled corticosteroids, will receive either ginger extract or a place…

This trial tests a new approach to pulmonary rehabilitation, a standard programme of exercise and education for people with chronic lung disease. The twist is that informal carers, often family members, join the education and support sessions. The goal is to see if this carer-inc…

This phase 3 trial is testing whether an experimental drug called felcorekibart, when added to standard asthma care, can reduce the number of severe asthma attacks in adults and adolescents whose asthma is not well controlled. Participants will receive either felcorekibart or a p…

This phase 3 trial is testing whether an investigational drug called felcorekibart, when added to standard asthma care, can reduce the number of serious asthma attacks in adults and adolescents (ages 12-80) whose asthma is not well controlled. Participants will receive either fel…

This Phase 3 trial is testing whether an investigational drug called tilrekimig can reduce the number of severe asthma attacks in adults and adolescents with a history of frequent exacerbations. Participants will receive either tilrekimig or a placebo as a subcutaneous injection,…

This study is testing whether tezepelumab, an injectable medication, can help people with severe asthma caused by allergic bronchopulmonary aspergillosis (ABPA), a condition where the immune system overreacts to certain fungi. The trial will enroll 10 adults aged 18 to 75 who hav…

This trial compares two exercise programs—Pilates and low-volume high-intensity interval training (HIIT)—to see which better improves cardiorespiratory fitness in adults with asthma. Fifty-one overweight participants aged 30 to 40 with partially controlled asthma will follow one …

This trial tests whether a structured care pathway — based on standard asthma guidelines — can improve disease management for adults with uncontrolled asthma who already use high-dose inhalers. Doctors and nurses at some clinics will receive extra training and tools to follow the…

This study compares two breathing exercises—box breathing and rhythmic breathing—to see which better reduces breathlessness, improves lung function, and enhances sleep quality in adults with mild to moderate asthma. Participants are randomly assigned to one of the two techniques …

This study tests a new drug, linvemastat, for adults with moderate-to-severe asthma that is not fully controlled by standard inhalers. About 135 participants will receive either one of two doses of linvemastat or a placebo, while continuing their usual medications. Over 16 weeks,…

This study tests whether taking chromium picolinate daily for 12 weeks improves asthma control in obese adults. Researchers believe that chromium may help by addressing metabolic issues like insulin resistance that can worsen asthma. Sixty participants will receive either the sup…

This study tests whether frequent sauna baths can reduce or eliminate bacteria that cause stubborn lung infections in people with conditions like COPD, asthma, or bronchiectasis. Researchers will track how long participants go without needing antibiotics and whether the bacteria …

This study observes 210 patients in South Korea who are prescribed Tezepelumab for severe asthma or chronic sinusitis with nasal polyps. Researchers will track side effects and how well the drug controls symptoms in everyday use. The goal is to confirm the drug's safety and effec…

This study tests whether text-message reminders and coaching can help 389 teens (ages 12-18) with moderate to severe asthma take their daily inhaled steroids as prescribed. Participants will be split into three groups: one gets a basic asthma app, another adds personalized text r…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests a family-empowered pulmonary rehabilitation program for school-age children (6-12 years) with asthma. The program includes education, skills training, and home-based guidance. Researchers will compare it to standard care in 92 children to see if it improves asthm…

This large study aims to create a digital screening and management system for adults with asthma and allergies. Nearly 10,000 participants will use a smartphone platform to track symptoms and receive guidance on three non-drug strategies: avoiding allergens (like dust mites), inc…

This study will test whether a 12-week vegan diet can lower inflammation in adults with mild to moderate asthma compared to a balanced omnivorous diet. Researchers will measure immune markers and asthma control in 280 participants aged 18-30. The trial is not yet recruiting.

This study tests a digital health assistant called 'Alex' to help children and teens aged 10 to 19 with asthma. Over six months, the app tracks lung function, symptoms, and medication use, and later gives personalized advice. The goal is to see if it improves asthma control and m…

This study tests two ways to use asthma inhalers to prevent serious attacks. One strategy (MART) uses a combination inhaler for daily control and quick relief. The other (PARTICS) adds a separate steroid inhaler whenever a rescue inhaler is used. About 4,100 adults with moderate-…

This early-phase trial is testing whether inhaling tiny particles from stem cells (called small extracellular vesicles) can safely help people with both allergic rhinitis and asthma. About 18 adults will receive either the active treatment or a placebo via nebulizer daily for two…

This study tests whether a slow-release form of the hormone DHEA can improve asthma control in adults aged 18 to 50. Standard asthma steroids can lower the body's own DHEA, so supplementing it might help. The trial will compare DHEA capsules to a placebo in 30 participants, measu…

This Phase 2 study tests a new drug called AK139 in 160 people with moderate to severe asthma. Participants receive either AK139 or a placebo by injection under the skin. The trial measures changes in lung function and asthma control over time, while also checking for side effect…

This study tests whether installing a radon mitigation system in homes can improve asthma symptoms. Researchers will compare a real system to a sham (inactive) system in 180 adults with uncontrolled asthma. The goal is to see if lowering radon levels leads to fewer days with asth…

This study looks at adults with asthma that is not well controlled by their current medium-dose inhaler. Researchers want to see if switching to a higher dose or a different type of inhaler can improve the function of the small airways in the lungs. About 130 participants will be…

This Phase 3 trial tests a new inhaler called N0783 against a standard asthma inhaler (Alenia) in 174 adults with moderate asthma. The goal is to see if the new drug works just as well at improving lung function and controlling symptoms. Participants will be randomly assigned to …

This study tests whether a new drug called QL2302 works as well as the approved drug Tezspire for people with severe asthma that is not controlled by current treatments. About 636 adults aged 18-80 will receive injections every 4 weeks for 48 weeks, then be monitored for another …

Researchers at Children's Hospital Los Angeles are testing a prototype wearable stethoscope that records lung sounds in children and adolescents with asthma aged 4 to 17. The study compares the device's recordings with those from a standard digital stethoscope to see if it can ac…

This study tests whether a new breathing measurement, called respiratory admittance, can better identify children who have asthma triggered by exercise. Children aged 5 to 16 who are already scheduled for an exercise challenge test will have their breathing measured using this ne…

This study evaluates a portable device that measures lung function using oscillometry—a technique that sends gentle sound waves into the lungs—to diagnose chronic respiratory diseases like COPD, asthma, and bronchiectasis. Researchers will enroll about 4,000 adults across 50 cent…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study will collect cough sounds, breath sounds, and symptom questionnaires from 1,400 children with respiratory symptoms like cough or fever. Researchers will use this data to build a computer model that can help diagnose conditions like asthma and pneumonia. The goal is to …

This study is testing a new, easy way to diagnose asthma and COPD using a handheld device that measures carbon dioxide in a person's breath. Instead of the current uncomfortable and time-consuming lung tests, participants simply breathe normally into the device for 75 seconds. Th…

This study will check how well two simple questionnaires (GINA-P and ACT-P) measure asthma control in adults. About 144 people with asthma will answer questions about their symptoms and take a breathing test. The goal is to see if these questionnaires can reliably tell if someone…

This pilot study tests a 12-month structured nursing program called RESPiraIA-Asma for adults with poorly controlled, non-severe asthma. The program combines education, inhaler training, home peak-flow monitoring, and personalized care plans, offered in-person, digitally, or mixe…

This study tests whether an extra virgin olive oil and water mouthwash can remove more leftover asthma medication from the mouth than plain water. The medication residue can cause problems like thrush or sleep apnea. Twenty healthy adults and adults with asthma will rinse with di…

This trial tests whether a 12-week virtual breathing training program can improve quality of life in adults with asthma that is not fully controlled by medication. Participants are randomly assigned to either the online breathing program or usual care. The program includes weekly…

This Phase 2 trial tests whether inhaled ketamine can improve breathing in children aged 1 to 13 with severe asthma attacks that do not respond to standard treatments. Participants receive either nebulized ketamine or a placebo every six hours for 24 hours, alongside usual care. …

This pilot study tests whether anakinra, a drug that reduces inflammation, can help people with moderate asthma attacks. 60 adults at high risk for asthma attacks will either receive anakinra or a placebo at home when they feel an attack starting. The study will check if this app…

This study checks if a new propellant (HFA-152a) in asthma inhalers is as safe as the current one (HFA-134a). About 110 adults with asthma will use both types of inhalers and be monitored for side effects. The goal is to make sure the new propellant is safe for everyday use.

This study tests whether adding exercise sessions and asthma education to usual care helps children aged 10-17 manage their asthma better. 60 participants will be randomly placed into one of three groups: usual care only, education only, or exercise plus education. The goal is to…

This study tests whether wearing a special LED vest for 20 minutes twice a week can improve lung function and exercise ability in children aged 6 to 17 with mild to moderate asthma. The vest uses light to reduce inflammation without heat. Half the children will get the active ves…

This study tests whether acupuncture can help people with mild-to-moderate chronic asthma breathe better and feel less anxious or depressed. 180 adults will be randomly assigned to real acupuncture, fake acupuncture, or usual care. The main goal is to see if real acupuncture impr…

This study tests whether a supervised exercise and education program (pulmonary rehabilitation) can help people with long-term lung diseases like COPD, asthma, and post-TB lung damage in Nigeria, South Africa, and Cameroon. Researchers will enroll 90 patients to see if the progra…

This study looks at whether replacing gas stoves with portable electric hot plates and toaster ovens can improve indoor air quality and asthma control. About 20 adults with poorly controlled asthma who cook with gas at least three times a week will participate. Researchers will m…

This study tests a new digital program designed to help people with moderate to severe asthma manage breathlessness and increase physical activity. Researchers will compare the program to usual care in 300 adults. The goal is to see if the program improves quality of life and ast…

This study tests whether a program called Body Awareness Therapy can help adults with asthma improve their physical function, breathing, and emotional well-being. 67 adults with stable asthma will be randomly assigned to either the therapy group or standard care. The therapy incl…

This study compares two types of inhalers—pressurized metered dose inhalers (pMDI) and dry powder inhalers (DPI)—to see which delivers asthma medication more effectively. Researchers will enroll 210 patients with uncontrolled asthma and measure changes in symptom control after 8 …

This early-stage trial tests a single oral dose of ADO-5030 in 36 adults with mild-to-moderate asthma. Researchers will check safety and how the drug affects breathing during a controlled airway challenge. The goal is to gather initial data, not to prove the drug works yet.

This study tests whether adding a Chinese herbal formula called Liqin Zhike to standard asthma inhalers (ICS/LABA) can reduce the chance of cough returning in people with cough variant asthma. About 236 adults aged 18 to 70 who are newly diagnosed will take either the inhaler alo…

Researchers are testing whether specialized tests of airway inflammation and lung abnormalities can predict asthma remission and relapse better than standard clinical assessments. The trial enrolls adults with severe asthma who are starting biologic therapy. Participants are rand…

Researchers are following about 1,200 children in Zhejiang Province, China, from birth through age 7 to understand how the immune system develops and why some children get more respiratory infections or asthma. The study includes healthy children, children with a history of serio…

This study aims to create a large collection of lung and airway tissue samples from people with COPD, asthma, and healthy volunteers. Researchers will gather samples through bronchoscopy, sputum, nasal brushing, and blood draws during routine procedures or surgeries. The goal is …

This study examines whether vitamin D levels are linked to asthma control, lung function, and oxidative stress in Egyptian adults with bronchial asthma. Researchers will measure vitamin D in the blood, assess asthma symptoms with a standard test, and check lung function and marke…

This study is testing whether three simple blood test measurements — the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-lymphocyte ratio (ELR), and systemic immune-inflammation index (SII) — can help assess how well asthma is controlled in adults. Researchers will compare th…

This study uses a quick, non-invasive breath test (FeNO) to measure airway inflammation in adults with asthma who are treated in primary care or community specialty clinics. The goal is to see how many patients have type 2 inflammation, which often goes undetected. Researchers ho…

This study will measure leg and handgrip strength in about 2,800 healthy adults and people with chronic lung diseases across Spain, Portugal, and Italy. Researchers want to create normal muscle strength values for these populations and see if the same standards can apply to peopl…

This study aims to find out how often people with FLNA gene mutations develop emphysema, a type of lung disease. Researchers will use chest CT scans, blood tests, and lung function tests in 70 participants. The goal is to confirm if FLNA changes are a cause of unexplained emphyse…

This study will expose 24 healthy adults to different levels of wildfire smoke in a safe, controlled room to see how it affects their lungs and brain. Researchers want to understand why some people may be more vulnerable to long-term lung diseases like asthma, COPD, and lung canc…

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This study will look at how well asthma is controlled in 42,000 children in China and what types of airway inflammation they have. Researchers will use tests to measure asthma control and inflammation patterns. The goal is to find ways to improve treatment, educate families, and …

This study will ask 460 teenagers with asthma in China to fill out questionnaires about their asthma control, anxiety, depression, and self-care skills. The goal is to understand how mental health and disease management are connected in this age group. No new treatments or medica…

This study follows 270 preterm babies (born before 32 weeks) from birth to age 3. Researchers will regularly swab their noses to analyze the bacteria and other microbes living there. The goal is to see if the nose microbiome can predict which babies will develop bronchopulmonary …

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study will analyze data from 500 adults to see if depression and asthma are connected, and if one might cause the other. Researchers will use medical records and genetic information to identify factors like age, smoking, or weight that could influence the link. No new treatm…

This study will enroll 120 adults with asthma or COPD to see how changes in lung function tests (spirometry and impulse oscillometry) relate to how much their breathing improves after using a bronchodilator. Participants will take a standard reversibility test and report their sy…

This study will test whether a brief educational session led by a nurse can help children aged 6-17 with asthma better manage their condition and use their inhaler correctly. The session covers understanding treatment, distinguishing between maintenance and rescue medications, an…

This study uses artificial intelligence to understand how air pollution and climate change impact respiratory diseases like allergic rhinitis and asthma. Researchers will gather health data from about 1,900 patients across Europe and analyze it with AI tools to find better ways t…

This study tests whether watching a medical TV drama can improve asthma knowledge in people aged 18–35 without medical backgrounds. About 48 participants from different countries will be randomly assigned to watch the drama or not. Researchers will measure changes in asthma-relat…

This study looks at how other health problems (comorbidities) and certain substances in the blood (biomarkers and microRNAs) affect asthma severity and treatment response in children aged 6 to 12. Researchers will track 82 children for one year to see which kids improve their lun…