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Scientists probe hidden link between depression and asthma

NCT ID NCT07377552

Knowledge-focused Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study will analyze data from 500 adults to see if depression and asthma are connected, and if one might cause the other. Researchers will use medical records and genetic information to identify factors like age, smoking, or weight that could influence the link. No new treatments are being tested—this is about understanding the relationship better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could clarify whether depression causes asthma or vice versa, guiding future prevention or treatment strategies.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect definitively, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Retrospective Study: Participants aged ≥ 18 years who had complete medical records (including demographic characteristics, clinical diagnosis, treatment plan, and follow-up records) between January 2015 and December 2020. Individuals with comorbid severe mental illnesses, severe respiratory diseases, severe organ failure, or missing key information in medical records were excluded. MR Study: Participants of European ancestry, with data sourced from the PGC (Psychiatric Genomics Consortium) major depressive disorder GWAS dataset, and the combined asthma GWAS dataset from UK Biobank and GABRIEL Consortium.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria For Retrospective Study * Age ≥ 18 years old * Complete medical records, including demographic characteristics (age, gender, ethnicity, etc.), clinical diagnosis information (diagnosis time of depression/asthma, diagnostic basis), treatment plans (medication type, dosage), and follow-up records * Depression diagnosis conforms to relevant clinical criteria; asthma diagnosis conforms to Guidelines for the Prevention and Treatment of Bronchial Asthma (2020 Edition) For MR Study (GWAS Data) * Data have undergone strict quality control * Study participants are of European ancestry (to reduce population stratification bias) * Clear division of case group and control group, as well as available sample size information Exclusion Criteria For Retrospective Study * Comorbidity with other severe mental illnesses (e.g., schizophrenia, bipolar affective disorder) * Comorbidity with severe respiratory diseases (e.g., chronic obstructive pulmonary disease \[COPD\], pulmonary fibrosis, lung cancer) * Comorbidity with severe organ failure (e.g., heart, liver, or kidney failure) * Lack of key information in medical records (e.g., diagnosis time, core symptoms, treatment plan) For MR Study (IVs Screening) * Single nucleotide polymorphisms (SNPs) with an association significance P-value ≥ 5×10-⁸ with the exposure (depression/asthma) * SNPs with high linkage disequilibrium (LD, r² ≥ 0.001, distance ≤ 10000 kb) * SNPs located in coding regions or those that may affect gene expression regulation (at risk of horizontal pleiotropy) * SNPs with an F-statistic \< 10 (at risk of weak instrumental variable bias)

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Conditions

The condition(s) this trial relates to.

asthma depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression，asthma

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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