Articular cartilage disorder

This study tests whether a lab-grown cartilage implant (MACI) works better than a standard surgery (microfracture) for teens aged 10-17 with knee cartilage damage. About 45 participants will receive either treatment and be followed for improvements in pain and sports function. Th…

This study tests whether adding a 3D-printed patch made from a patient's own knee fat tissue to standard microfracture surgery helps regrow knee cartilage better than surgery alone. About 104 adults with large cartilage defects will be randomly assigned to one of the two treatmen…

This Phase 3 trial tests whether a lab-grown cartilage implant (MACI) can better repair painful ankle cartilage defects than the standard microfracture procedure. About 309 adults aged 17-65 with ankle cartilage damage will be randomly assigned to receive either MACI or microfrac…

This trial tests a new partial knee implant called BioPoly for people with knee cartilage damage and pain. Participants are randomly assigned to receive either the implant or standard surgery (microfracture or debridement). The study measures success by pain and function improvem…

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. Seventy participants will be randomly assigned to receive either real-time biof…

This study tests a new way to repair damaged knee cartilage. Doctors take stem cells from the patient's bone marrow, grow them into cartilage in the lab, and then implant it into the knee. The trial includes 30 adults aged 18 to 65 with cartilage injuries or early knee osteoarthr…

This study is testing a procedure called autologous chondrocyte implantation (ACI) for people with knee cartilage defects. Doctors take a sample of the patient's own cartilage cells, grow them in a lab, and then implant them into the damaged area. The goal is to see if this appro…

This pilot study compares two surgical techniques for repairing damaged hip cartilage in 40 people aged 18 to 55. One group receives standard microfracture surgery, while the other gets an enhanced procedure called AMIC, which uses a collagen patch to protect the repair site. Res…

This study tests a new injection called CartiPRO to see if it can safely reduce knee pain in people with osteoarthritis. About 194 adults will receive either CartiPRO or another approved injection, and then get a second shot 24 weeks later. Researchers will measure pain and knee …