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Your own stem cells could grow new knee cartilage

NCT ID NCT07094100

Disease control Sponsor: The First Affiliated Hospital of Xinxiang Medical College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a new way to repair damaged knee cartilage. Doctors take stem cells from the patient's bone marrow, grow them into cartilage in the lab, and then implant it into the knee. The trial includes 30 adults aged 18 to 65 with cartilage injuries or early knee osteoarthritis. The goal is to see if this lab-grown cartilage can improve knee function and reduce pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lab-grown cartilage from the patient's own bone marrow stem cells
What this could lead to
If it works, this could offer a new way to repair damaged knee cartilage without joint replacement, potentially improving mobility and reducing pain.
What could go wrong
This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The lab-grown cartilage may not integrate well or could cause complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. The patients' age ranges from 18 to 65 years old, and gender is not restricted; 2. The imaging results show that the epiphyseal growth is mature; 3. The defects or localized injuries of joint cartilage caused by trauma or other reasons; 4. The injured area is the distal weight-bearing surface of the femoral condyle of the knee joint, with no more than 4 lesions, and there is no injury to the cruciate ligaments; 5. The patients voluntarily sign and provide a written informed consent form and are willing to closely cooperate with the doctor's strict postoperative rehabilitation program. Exclusion Criteria: 1. The patient is extremely overweight, with a body mass index greater than 35; 2. The lower limb alignment is valgus by more than 10° and varus by more than 5°; 3. Multiple ligament injuries; 4. There are numerous bad habits such as heavy smoking, drug abuse, and excessive alcohol consumption; 5. Has undergone open knee joint surgery within the past six months; 6. Has severe joint stiffness or fibrosis; 7. Has an allergic constitution or a history of allergic reactions to collagen; 8. Has mental abnormalities; 9. Cannot or is unwilling to undergo rehabilitation training; 10. Has primary cardiovascular diseases, lung diseases, endocrine and metabolic disorders, or other serious diseases that affect their daily life, such as tumors or AIDS; 11. Pregnant or lactating women, or those planning to conceive during the trial period; 12. Other acute or chronic diseases, for which the researchers consider surgery to be inappropriate.

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Conditions

The condition(s) this trial relates to.

articular cartilage disorder osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cartilage injury Oa knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The First Affiliated Hospital of Xinxiang Medical College

    RECRUITING

    Xinxiang, Henan, 453000, China

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