Aortic valve disease 2

This study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…

This study tests a home-based cardiac rehabilitation program delivered through a custom app for people who have had a heart valve procedure. Participants who choose not to attend center-based rehab are randomly assigned to usual care, the app with self-guided content, or the app …

This study tests a new device called Rapidlink, used during open surgery to repair or replace blood vessels in the chest. It involves 150 adults already scheduled for aortic surgery. The goal is to see if the device reduces major complications like stroke or death. Participants w…

This study tests whether a newer blood thinner (rivaroxaban) works as well as the standard drug (warfarin) for preventing clots and bleeding in people who have a mechanical aortic valve. About 1,300 adults who had valve surgery at least 3 months ago will take one of the two pills…

This study compares aspirin to the blood thinner warfarin in 1058 people who just had a bioprosthetic heart valve replacement. For 6 months after surgery, participants take either daily aspirin or warfarin. The goal is to see if aspirin is just as safe and effective at preventing…

This study is testing a new type of biological heart valve that features an 'easy change' system, designed to make future replacements simpler. Researchers will implant these valves in 500 people with aortic valve disease and track complications like blood clots, infections, and …

This study tests a pre-set treatment plan for managing heart rhythm issues that can occur after transcatheter aortic valve replacement (TAVR). The goal is to reduce the number of patients who receive a permanent pacemaker while ensuring no one is put at risk of sudden cardiac dea…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study looks at how safe and effective a less invasive heart valve replacement (called Sapien 3 TAVR) is for younger patients (ages 50-70) in China with severe aortic stenosis. Researchers will track 450 participants for up to 5 years to see survival rates and complications. …

This study follows 225 adults who have the Ross procedure, a surgery that replaces a diseased aortic valve with the patient's own pulmonary valve. Researchers will track survival, hospital readmissions, and need for repeat surgeries over 1, 5, and 10 years. The goal is to confirm…

This study tests a special balloon that uses shockwaves to crack calcium buildup in the iliac arteries, making it possible to deliver large aortic stents. About 40 adults with severe aortic disease and hardened arteries will be enrolled. The goal is to see if this approach is saf…

This study tests a new surgical technique called the 'Y incision' for people with a small aortic annulus (the ring where the heart valve sits) who need aortic valve replacement. The standard methods often limit how large a replacement valve can be placed, which can lead to poor b…

This clinical trial is testing two different surgical methods to repair a bicuspid aortic valve, a common heart defect where the valve has two flaps instead of three. The study will enroll 100 people with this condition who also have a leaky valve (aortic regurgitation). Half wil…

This study tests an artificial intelligence (AI) model that can screen for heart valve disease using standard chest CT scans that people already get for other reasons. The goal is to see how well the AI catches moderate-to-severe cases without needing extra tests or contrast dye.…

This study investigates whether a blood test measuring clotting and clot-busting markers can predict complications in patients undergoing aortic valve replacement. Researchers will follow 750 adults with aortic stenosis who receive either surgical or catheter-based valve replacem…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

This study explores whether kinocardiography (KCG), a portable device that measures chest vibrations from heartbeats, can diagnose aortic valve disease and thoracic aortic aneurysm. Researchers will compare KCG readings with standard imaging in 180 adults, including those with an…

This study is testing whether a small implantable heart monitor (Reveal LINQ) can detect serious heart block in people who develop a new electrical problem (left bundle branch block) after having their aortic valve replaced (TAVI). About 80 participants will get the monitor and b…

This study is testing whether having a dental checkup before heart valve surgery can prevent serious complications like infection of the heart lining, repeat surgery, or death. About 1,300 adults scheduled for valve surgery will be randomly assigned to either get a dental screeni…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This registry will follow 2,500 people who receive Abbott heart devices, such as implants for holes in the heart or replacement heart valves. The goal is to check how safe and effective these devices are when used in everyday hospital practice. Data will be collected from standar…

This study is tracking 500 people who receive the INSPIRIS RESILIA aortic valve during surgery. Researchers will measure how well the valve works by checking blood flow and leakage over time. The goal is to see how the valve performs in everyday medical practice.

This study at Mayo Clinic looks at how changes in the blood vessels of the lungs affect people with heart valve disease. Researchers will use echocardiograms during routine heart catheterization to measure these changes in 600 adults scheduled for valve procedures. The goal is to…

This study tracks 300 adults with aortic disease to measure how their condition impacts quality of life, fatigue, mental health, and ability to work. Researchers will use questionnaires over 12 months to gather data. The goal is to better understand these challenges and help desi…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study tests whether artificial intelligence (AI) can help cardiologists read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to doctors in real time as they review heart images from 50 participants with valve disease. The …

This study is a registry that will follow up to 2,700 people who have received or will receive a Medtronic heart valve product during surgery. The goal is to monitor the long-term safety and performance of these devices by identifying any unexpected problems or trends. Participan…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This observational study is testing whether advanced heart imaging (MRI or CT scans) can find blood clots in the heart that standard ultrasound might miss. It involves 125 people who had a stroke of unknown cause and have mild heart disease. The goal is to better understand strok…

This study uses artificial intelligence to analyze data from 21,000 patients who had heart valve procedures. The goal is to make AI tools that can predict surgery outcomes, like which device to use and risks of complications, with over 90% accuracy. This is a non-interventional s…

This registry will track 800 adults with valvular heart disease to see if women and men receive different diagnosis, treatment, and follow-up care. Researchers will compare how quickly each group gets guideline-recommended therapies and whether gender, age, or ethnicity affect ou…

This study looks at whether common blood tests for heart damage (troponin and CK-MB) match what an MRI shows after heart valve surgery. Researchers will enroll 100 adults having aortic or mitral valve surgery. The goal is to improve how heart attacks are diagnosed after surgery, …

This study is following 4,000 people with heart valve disease to look for new substances in the body (called metabolites) that might be linked to the disease. Researchers hope to find better ways to predict who will get worse and understand why. No new treatments are being tested…