Anal fistula

Researchers are testing a combination treatment for people with recurrent cryptoglandular perianal fistula, a painful tunnel that keeps coming back after surgery. The study enrolls 25 adults who have had at least two failed fistula operations and have a seton drain in place for a…

This trial tests whether a 7-day course of antibiotics after draining a first-time perianal abscess can stop an anal fistula from forming. Adults with a first abscess are randomly assigned to receive antibiotics or not, then followed for up to 12 months. The goal is to see if ant…

This trial tests whether preparing the bowel before fistula laser closure surgery helps the wound heal better. Anal fistulas are abnormal tunnels that can form near the anus, and laser closure is a technique to seal them while sparing the muscle. Researchers will compare two grou…

This trial tests whether a minimally invasive laser procedure can close low perianal fistulas as effectively as traditional open surgery. Adults with a primary low perianal fistula are randomly assigned to receive either laser closure or open fistulectomy. Researchers track heali…

This trial is testing whether combining the drug mirikizumab with a surgical procedure can help heal perianal fistulas in people with Crohn's disease. Participants will receive the drug through infusions and injections, along with two surgical steps to clean and close the fistula…

This study compares two ways to treat uncomplicated perianal fistula: conventional open surgery (fistulectomy) and a newer laser ablation technique. About 72 adults with a single, simple fistula tract will be randomly assigned to one of the two procedures. Researchers will track …

This Phase 2 trial tests whether E-CEL UVEC Cells, a type of genetically engineered cell, can treat perianal fistula—a painful tunnel that forms near the anus. The treatment involves injecting the cells directly into the fistula tract in a minimally invasive procedure. Researcher…

This pilot study tests whether a device that delivers controlled heat (radiofrequency ablation) can safely close perianal fistulas—abnormal tunnels between the anal canal and skin. Eighty adults with certain types of fistulas will receive a single RFA treatment. Researchers will …

This study compares three surgical techniques for treating a common type of anal fistula (a tunnel between the anal canal and skin). The trial will enroll 90 adults aged 18-65 who have not had fistula surgery before. Researchers will measure healing, recurrence, and impact on bow…

This study will check how well MRI can find and map perianal fistulas before surgery. Thirty patients with suspected fistulas will get an MRI, and the results will be compared to what surgeons find during the operation. The goal is to see if MRI can help doctors plan better surge…

A loose seton is a thread surgeons place through a complex anal fistula to keep it draining. This pilot study follows 50 adults who already have a polypropylene seton and whose surgeon decides, as part of routine care, to replace it with a braided polyester one. Researchers ask e…

This study tests whether Shouhui Tongbian Capsules, a traditional Chinese herbal medicine, can relieve constipation after surgery for benign anal or rectal conditions like hemorrhoids. 120 adults will be randomly assigned to take either the herbal capsules or a standard laxative …

This study tests whether doing pelvic floor exercises (called anal lift exercises) and changing diet early after anal fistula surgery can help reduce pain, bleeding, and discomfort. About 124 adults aged 18 to 55 who have had anal fistula surgery will be split into two groups: on…

This study tests whether injecting platelet-rich plasma (PRP) into the wound after fistulotomy surgery for simple anal fistula can speed healing and reduce pain. About 70 adults aged 18-65 with simple low anal fistulas will be randomly assigned to get either standard surgery plus…

This study will follow 120 women having surgery for common anal conditions like fissures, hemorrhoids, or fistulas. Researchers want to see if their sexual function improves after surgery. Participants will fill out questionnaires before surgery and at 3 and 6 months after. The g…

This study will observe 90 adults with anal fistulas to see if the time between first symptoms and surgery affects healing and recurrence. Participants are grouped by how long they waited: 3 months or less, 3 to 6 months, or more than 6 months. Researchers will track healing, rec…

This study tests whether using the 'teach-back' method—where patients repeat back what they've learned—improves understanding and reduces readmissions after same-day anal fistula surgery. Half of the 76 participants will get this interactive education, while the other half receiv…