Alcoholic hepatitis

Researchers are testing whether adding TAK-242 and G-CSF to standard care is safe and more effective than standard care alone for people with severe alcoholic hepatitis and acute-on-chronic liver failure (ACLF). TAK-242 aims to block an immune system overreaction, while G-CSF enc…

This Phase 3 trial tests an experimental drug called larsucosterol in 350 people with severe alcohol-associated hepatitis. The goal is to see if the drug helps patients survive for 90 days without needing a liver transplant. Participants receive either the drug or a placebo by IV…

This study tests whether adding alcohol use disorder treatments (acamprosate and counseling) to standard liver therapy improves outcomes for people with severe alcohol-associated hepatitis. It also compares a new drug, F-652, against prednisone for liver treatment. About 216 adul…

This study tests whether a combined computer- and counselor-delivered alcohol treatment program can help people who receive an early liver transplant for severe alcoholic hepatitis stay alcohol-free. Researchers will compare this program to standard care in 200 participants, trac…

This phase 3 trial tests whether adding N-acetylcysteine or extending prednisolone treatment beyond the standard 30 days can improve outcomes for people with severe alcoholic hepatitis. About 477 participants will be enrolled. The goal is to see if these strategies increase the n…

This study tests whether adding N-acetylcysteine (NAC) to standard steroid treatment helps people with severe alcoholic hepatitis live longer and have fewer complications. About 390 adults aged 18-75 with a high Maddrey score will be enrolled. The main goal is to see if the combi…

This early-phase trial at the Cleveland Clinic is testing whether a form of hyaluronic acid (HA35) can help prevent muscle loss in people with alcoholic hepatitis. 54 participants will take either HA35 or a placebo capsule daily for 90 days. The study involves two in-person visit…

This study tests whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) for 6 months can help people with alcohol use disorder reduce heavy drinking and improve liver health. Researchers will compare the probiotic to a placebo in 60 adults who drink heavily. The goal …

Researchers are studying whether a blood test called HepQuant DuO can measure liver function over time in people with alcohol-related liver disease. Participants drink a natural compound called cholate, then give two blood samples at 20 and 60 minutes. The study follows about 40 …

This study looks at how inflammation and liver repair differ in people with alcoholic hepatitis versus those with alcoholic cirrhosis or healthy livers. Researchers will collect blood, liver tissue, and fluid samples from 450 participants. The goal is to better understand what dr…

This study is observing heavy drinkers with jaundice to learn more about alcoholic hepatitis, a serious liver condition. Researchers will track survival and liver function over 12 months, and collect genetic samples to better understand the disease. The goal is to improve diagnos…

This study looks at bacteria found in the liver, blood, and stool of 50 people with severe alcoholic hepatitis. Researchers want to see if these bacteria are linked to how well patients respond to treatment and their overall survival. The goal is to find new ways to treat this se…

Acute alcoholic hepatitis is a serious liver condition with a high risk of death, but current prediction tools are limited. This study will analyze data from 1,400 patients to find more accurate markers of prognosis. By integrating clinical, lab, and tissue information, researche…

This study collects blood and urine samples from 500 people with alcoholic liver disease, heavy drinkers without liver disease, and healthy non-drinkers. The goal is to create a biorepository that researchers can use to study biomarkers and improve understanding of the disease. P…

This study compares immune cell function in 30 healthy volunteers, heavy drinkers, and people with alcoholic hepatitis. Researchers will analyze blood samples to measure how mitochondria (the cell's powerhouses) work and how cells respond to inflammation. The goal is to better un…