Advanced heart failure

Researchers are testing whether a standardized care pathway helps adults with advanced heart failure in Latin America complete a multidisciplinary evaluation and receive a documented treatment decision within 90 days. The trial includes 360 adults with acquired or structural hear…

This study tests an experimental oral drug called AC01 in 400 people with chronic advanced heart failure and a weak heart pump. The goal is to see if AC01 can safely improve heart function over 12 weeks compared to a placebo. Participants will have heart ultrasounds and blood tes…

This trial explores whether a single, low-dose radiation treatment to the heart can improve pumping function in people with advanced or end-stage heart failure. The study includes 20 adults with severe heart failure who are not eligible for a transplant or mechanical heart pump. …

This study compares two blood thinners—apixaban (Eliquis) and warfarin (Coumadin)—in 460 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents strokes, pump clots, and serious bleeding. Participants must have had their…

This trial is testing a new mechanical heart pump called the DuoCor 2, designed to support both sides of the heart in people with advanced heart failure. The study will enroll 64 patients who are severely ill and need circulatory support. The main goal is to see if the device hel…

This trial tests a device called the Corheart 6, a left ventricular assist system that helps pump blood in people with advanced left ventricular heart failure. The study includes 100 adults aged 18 to 75 with severe heart failure symptoms despite optimal medical therapy. The main…

This early-stage study tests a new treatment called HiCM-188, made from stem cells that become heart muscle cells. It is given as a single injection into the heart during bypass surgery in 12 adults with severe heart failure. The main goal is to check safety and see if it improve…

This study tests whether patients with a heart pump (LVAD) can safely stop taking aspirin while continuing warfarin. The goal is to reduce bleeding problems without increasing dangerous clots. About 370 participants will be randomly assigned to receive either aspirin or a placebo…

This study tests whether measuring sodium in urine can help doctors give the right amount of diuretics (water pills) to people hospitalized with worsening heart failure. About 260 adults will be split into two groups: one gets standard care, the other gets treatment guided by uri…

This study tests a new device called DuoCor 2, which is a mechanical pump that helps both sides of the heart pump blood. It is for people with advanced heart failure in both ventricles who have few other options. The study will enroll 50 adults and measure how many survive for 6 …

This study tests whether quickly starting and increasing guideline-recommended heart failure medications after hospitalization improves outcomes in women. About 360 women from 13 Italian hospitals will be randomly assigned to either a high-intensity care group (rapid drug optimiz…

This study tests a new adjustable cooler for storing donor hearts during transport to the transplant hospital. The cooler aims to keep the heart at a steady temperature, reduce waste, and lower costs compared to the current standard device. About 80 adults receiving a heart trans…

This study tests a new approach for people with end-stage heart failure and permanent atrial fibrillation who are waiting for a heart transplant or heart pump. Participants will receive either a standard implantable defibrillator (ICD) alone or an ICD plus a special pacing lead a…

This Phase 3 trial tests whether a continuous infusion of alprostadil, a drug that widens blood vessels, can help maintain stability in 600 people with advanced heart failure. Participants receive either the drug or a placebo for 6 months. The main goal is to see if the drug redu…

Researchers are testing whether continuous heart monitoring can lower unplanned hospital visits in adults with heart failure who have never shown signs of atrial fibrillation. One group receives a small monitor implanted under the chest skin, another uses a handheld device for we…

This study tests whether a new risk algorithm (FIND HF) can better detect undiagnosed heart failure in people at risk. About 475 adults aged 40+ will have a blood test and heart ultrasound. Researchers will compare how many high-risk vs low-risk people are found to have heart pro…

Researchers are studying whether donor hearts can be safely stored and transported at 10°C using a portable cooler called the X°Port Heart Preservation System. The trial enrolls up to 25 adults who are listed for heart transplantation. Participants receive a standard heart transp…

This study tests whether a 12-week home exercise program, guided by a mobile app and smartwatch, can improve exercise capacity and quality of life in people with a left ventricular assist device (LVAD). About 78 participants who recently got an LVAD and cannot attend hospital reh…

This study tests whether a supervised 8-week exercise program can improve physical function and exercise ability in people with advanced heart failure who are hospitalized and waiting for a heart transplant. Participants will do aerobic and resistance exercises while receiving IV…

This study looks at whether adding a palliative care team—specialists in comfort and holistic support—can improve quality of life for people who have had a mechanical heart pump (LVAD) for at least a year. About 90 adults who are not eligible for a heart transplant will be random…

This study follows 100 adults with advanced heart failure for 2 years to understand how kidney function changes over time and how it relates to serious heart events like death or need for a transplant. Researchers will collect blood, urine, and stool samples, along with quality-o…

This study tests a new, non-invasive device called ODIN that measures how well oxygen is being used in the tiny blood vessels of patients with advanced heart failure or cardiogenic shock in the ICU. About 30 adults will have their oxygen measurements taken with the device and com…

This study looks at 600 people (400 with chronic heart failure and 200 healthy) to find patterns in genes, proteins, and gut bacteria that may predict who gets worse. Researchers will track patients for one year to see who is hospitalized or dies. The goal is to create a better r…