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Heart-Kidney link under microscope in advanced heart failure study

NCT ID NCT07666516

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study follows 100 adults with advanced heart failure for 2 years to understand how kidney function changes over time and how it relates to serious heart events like death or need for a transplant. Researchers will collect blood, urine, and stool samples, along with quality-of-life surveys, and some participants will get a special kidney MRI. The goal is to better predict and manage the combined heart and kidney problems seen in these patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better predict and manage heart and kidney complications in advanced heart failure patients.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve health. It may not find clear links between kidney function and heart outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Nov 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written informed consent signed by the patient, * Age ≥ 18 years and ≤ 75 years, * Patient with advanced heart failure confirmed by criteria of severe cardiac dysfunction documented in a stable condition, with at least one of the following parameters at baseline: * LVEF ≤ 35%, * Elevated BNP or NT-proBNP levels (\>200 ng/L for BNP and \>1000 ng/L for NT-proBNP), * NYHA class ≥ 3, * At least one hospitalization for heart failure decompensation within the past 24 months, * Optimized medical treatment for heart failure according to French/European cardiology guidelines at the maximum tolerated dose for \>30 days. Exclusion Criteria: * Presence of severe extracardiac disease with a life expectancy \< 1 year, * Patient with end-stage renal disease (GFR \<15 mL/min/1.73 m²) or on dialysis, * History of heart, kidney, or other solid organ transplantation, * Patient in cardiogenic shock, * INTERMACS profile ≤ 3, * Pregnant, parturient, or breastfeeding women\*, * Individuals deprived of liberty by judicial or administrative decision, * Individuals under psychiatric care, * Individuals admitted to a health or social institution for purposes other than research, * Adults under legal protection (guardianship or curatorship), * Individuals not affiliated with a social security system or equivalent coverage. * Contraindication to multiparametric renal MRI combined with tissue sodium measurement using non-contrast 23Na MRI of the leg (including inability to undergo MRI as judged by the investigator).

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Conditions

The condition(s) this trial relates to.

advanced heart failure cardio-renal syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Advanced heart failure Cardiorenal syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospices Civils de Lyon

    Bron, Rhone, 69500, France

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