Advanced heart failure

This study tests an investigational drug called COR-1167 in 300 people hospitalized with worsening heart failure. Participants receive either the drug or a placebo for 28 days. Researchers measure how well the body removes fluid, changes in weight, heart function, and symptoms. T…

This study tests whether a mechanical heart pump called the HeartMate III (an LVAD) helps people with end-stage heart failure live longer and with fewer strokes compared to taking standard heart failure medications. About 80 adults with severe heart failure are randomly assigned …

This study is testing the Carmat Total Artificial Heart in 104 people with severe, irreversible heart failure who are waiting for a heart transplant. The device is designed to replace both heart chambers and keep patients alive until a donor heart becomes available. Researchers a…

This study compares a new heart pump (EVAHEART®2) to a current pump in 399 adults with severe heart failure. The goal is to see if the new pump helps people survive until a heart transplant or recover enough to have the pump removed, without suffering a disabling stroke or severe…

This study tests whether injecting lab-grown heart muscle cells (HiCM-188) into the heart during bypass surgery can safely help people with severe chronic heart failure. About 36 adults with damaged heart tissue and reduced pumping function will receive the cell injection. The ma…

This trial is testing a new mechanical heart pump called the Corheart 6 in 50 people with end-stage heart failure. The pump is implanted to help the heart circulate blood. Researchers are checking if the device works safely and effectively at 3 months and 2 years after implantati…

This study tests new strategies to make sure that decisions about who gets a heart transplant or a heart pump are fair and based on objective medical criteria, not bias. Researchers will work with over 1,400 patients and doctors at heart centers across the U.S. to reduce racial a…

This study looks at whether a quick, simple test—standing up and sitting down from a chair as many times as possible in one minute—can help predict how heart failure patients will fare after leaving the hospital. Researchers will follow 68 adults hospitalized for decompensated he…

This study looks at 120 adults getting a left ventricular assist device (LVAD) to see how often infections happen and how their immune system changes after surgery. The goal is to find what makes some patients more likely to get infections. This research does not test a new treat…