Experimental combo targets tough bone cancer in kids and adults

NCT ID NCT04833582

First seen Mar 21, 2026 · Last updated Apr 28, 2026 · Updated 3 times

Summary

This early-stage study tested a new drug (ZN-c3) combined with standard chemotherapy (gemcitabine) in 31 people aged 12 and older whose osteosarcoma (a type of bone cancer) had returned or stopped responding to treatment. The main goals were to check safety and see if the combination could slow or stop tumor growth. The study is complete, and results will help decide if further testing is warranted.

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Contacts and locations

Locations

  • Site 0103

    Houston, Texas, 77030, United States

  • Site 0105

    New York, New York, 10065, United States

  • Site 0106

    Los Angeles, California, 90095, United States

  • Site 0107

    Cincinnati, Ohio, 45229, United States

  • Site 0122

    Seattle, Washington, 98195, United States

  • Site 0123

    Portland, Oregon, 97239, United States

  • Site 0124

    Oakland, California, 94609, United States

  • Site 0188

    Richmond, Virginia, 23298, United States

  • Site 0193

    Memphis, Tennessee, 38105, United States

  • Site 0195

    Santa Monica, California, 90403, United States

  • Site 0197

    Nashville, Tennessee, 37332, United States

  • Site 3601

    Lyon, 69008, France

  • Site 3602

    Marseille, 13385, France

  • Site 3604

    Bordeaux, 33000, France

  • Site 3605

    Toulouse, 31100, France

  • Site 3606

    Paris, 75248, France

  • University of Florida College of Medicine

    Gainesville, Florida, 32610, United States

Conditions

Explore the condition pages connected to this study.