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Could vitamin d levels predict wheezing after bronchiolitis?

NCT ID NCT07700134

Knowledge-focused Sponsor: National and Kapodistrian University of Athens Source: ClinicalTrials.gov ↗

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Recruiting now
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Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Completed
The trial has finished. Results may not be published yet.
Stopped early
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Cancelled
Cancelled before anyone took part.

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Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates whether vitamin D levels, genetic variations in the vitamin D receptor, and changes in immune cell mitochondria can help predict which children will develop recurrent wheezing after a bout of bronchiolitis. Researchers will measure these markers in children under 2 hospitalized with bronchiolitis and compare them to healthy controls, then follow the children for 36 months to track wheezing episodes. The goal is to identify early biomarkers that could guide future prevention or treatment strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify biomarkers that predict which children are at risk for recurrent wheezing after bronchiolitis, potentially pointing toward preventive strategies.
What could go wrong
This is an observational study, not a treatment trial. It may find no clear link, and any identified biomarkers would need further validation before clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 130 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study will include children under 2 years of age who are diagnosed with bronchiolitis and hospitalized to the Second Pediatric Department and the Neonatal Unit of the 1st Pediatric Department of the National and Kapodistrian University of Athens at "Aghia Sofia" Children's Hospital. Diagnosis will be established according to the 2021 NICE criteria for bronchiolitis. The control group will consist of healthy children without bronchiolitis, matched to patients for gestational age, chronological age, and sex, at a 1:4 ratio. Controls will be recruited during the same period as the patients to ensure comparability of the two groups with respect to seasonality, which is known to affect serum vitamin D levels.

Ages

0 days to 24 months

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: The study will include children under 2 years of age who are diagnosed with bronchiolitis and hospitalized to the Second Pediatric Department and the Neonatal Unit of the 1st Pediatric Department of the National and Kapodistrian University of Athens at "Aghia Sofia" Children's Hospital. Diagnosis will be established according to the 2021 NICE criteria for bronchiolitis. The control group will consist of healthy children without bronchiolitis, matched to patients for gestational age, chronological age, and sex, at a 1:4 ratio. Controls will be recruited during the same period as the patients to ensure comparability of the two groups with respect to seasonality, which is known to affect serum vitamin D levels. Εxclusion Criteria: * Patients will be excluded from the study if they have a history of congenital heart disease, cystic fibrosis, bronchopulmonary dysplasia, immunodeficiency, use of immunosuppressive agents, prematurity with a gestational age of \< 32 weeks, or if their guardians refuse their participation in the study.

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Conditions

The condition(s) this trial relates to.

acute bronchiolitis bronchiolitis Respiratory Sounds

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bronchiolitis acute RSV Wheezing

Contacts and locations

Locations

  • "Aghia Sofia" Children's Hospital

    Athens, Attica, 11527, Greece

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