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Vitamin c may shield postmenopausal hearts without hormones

NCT ID NCT07109115

Disease control Sponsor: University of Virginia Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study tests whether vitamin C supplements can reduce oxidative stress and improve blood vessel function in healthy, sedentary postmenopausal women during exercise. Participants take different doses of vitamin C (0 mg to 1000 mg) for a few days before each exercise session. The goal is to see if vitamin C can offer heart protection similar to hormone therapy, but without the risks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vitamin C (ascorbic acid) taken as a dietary supplement in doses of 0 mg, 200 mg, 500 mg, and 1000 mg
What this could lead to
If it works, this could point toward a simple, non-hormonal way to protect postmenopausal women from heart disease.
What could go wrong
This is a very small, early study with only one participant, so results may not apply to others. Vitamin C may not reduce oxidative stress enough to improve blood vessel health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1 person

The number who actually took part.

Started

Sep 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Post-menopausal (for females; defined as no menstrual cycle for 1-year) * Sedentary (\<150min of moderate-intensity exercise per week or not engaged in a regular exercise program) * Non-smoking * Weight stable (+/-3 kg over the past 3 months) Exclusion Criteria: * Overt CVD * Any condition or medication contraindicating safe exercise * Hormone replacement therapy (last 3-months) * Use of vasoactive medications (e.g., calcium channel blockers, statins, ACE inhibitors, ARBs, nitrates, alpha-/beta-blockers, diuretics), diabetes, or unstable medication regimens * Diabetes * Oral antibiotic use within previous four weeks * Oral disease or poor oral health as determined by the Oral Health Questionnaire * Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use * Cancer diagnosis

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Conditions

The condition(s) this trial relates to.

Motor Activity Sedentary Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Females Healthy participants MALES Menopause Sedentary

Contacts and locations

Locations

  • Student Health and Wellness Building - Department of Kinesiology

    Charlottesville, Virginia, 22903, United States

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