Vitamin c may shield postmenopausal hearts without hormones

NCT ID NCT07109115

Terminated Disease control Sponsor: University of Virginia Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study tests whether vitamin C supplements can reduce oxidative stress and improve blood vessel function in healthy, sedentary postmenopausal women during exercise. Participants take different doses of vitamin C (0 mg to 1000 mg) for a few days before each exercise session. The goal is to see if vitamin C can offer heart protection similar to hormone therapy, but without the risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vitamin C (ascorbic acid) taken as a dietary supplement in doses of 0 mg, 200 mg, 500 mg, and 1000 mg
What this could lead to: If it works, this could point toward a simple, non-hormonal way to protect postmenopausal women from heart disease.
What could go wrong: This is a very small, early study with only one participant, so results may not apply to others. Vitamin C may not reduce oxidative stress enough to improve blood vessel health.

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Conditions

The condition(s) this trial relates to.

Motor Activity Sedentary Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FEMALES HEALTHY PARTICIPANTS MALES MENOPAUSE SEDENTARY

Contacts and locations

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Locations

Student Health and Wellness Building - Department of Kinesiology

Charlottesville, Virginia, 22903, United States

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