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Can computer training rewire the brain to restore sight after stroke?

NCT ID NCT06121219

Symptom relief Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers at the University of Rochester are testing a home-based computer program that trains people to detect visual stimuli in their blind field. The trial enrolls adults who have lost part of their vision because of damage to the brain's visual cortex, often from a stroke. Participants use the software daily for several months while researchers measure changes in visual perception and brain function. The goal is to learn whether intensive visual retraining can help recover some vision and how the brain adapts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
home-based visual retraining software
What this could lead to
If it works, this could offer a home-based way to help people regain parts of their vision after a stroke damages the brain's visual areas.
What could go wrong
The training may not improve vision outside the specific tasks practiced, and benefits might not carry over to everyday life. The trial is small and early, so results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Jan 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Cortically Blind Subjects Inclusion: * Between 21 and 80 years of age * Residents of the United States or Canada * Unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range (21-75 years) * Reliable visual field defects in both eyes as measured by Humphrey, MAIA, Goldmann, and/or equivalent perimetry, large enough to enclose a 5-deg diameter visual stimulus. * Able to fixate on visual targets reliably for 1000ms * Must have a home computer (desktop or laptop) and reliable internet access * Willing, able, and competent to provide informed consent * Normal cognitive abilities, able to understand written and oral instructions in English, and competent and responsible adults in order to complete the visual training at home, independently, as instructed, for several months. Exclusion: * Past or present eye disease interfering with visual acuity * BCVA worse than 20/40 in either eye * Damage to the dorsal Lateral Geniculate Nucleus * Diffuse whole brain degenerative processes * History of traumatic brain injury * Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures * Documented history of drug/alcohol abuse * Currently taking neuroactive medications which would impact training, as determined by PI * Presence of cognitive or seizure disorders * One-sided attentional neglect * Subjects who lack the competence or are otherwise unable to perform the visual training exercises as directed. Control Subjects (n = 50) Inclusion: * Between 21 and 80 years of age * Report no history of neurological disorder. * Competent and responsible, as determined by the Principal Investigator. Exclusion: * Presence of damage to the visual system * Presence of an active disease process involving their nervous system. * Cognitive or seizure disorders * Best corrected visual acuity worse than 20/40 in either eye * Presence of vision field loss from ocular disease or disorder

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Conditions

The condition(s) this trial relates to.

blindness (disorder) cortical blindness Hemianopsia ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cortical blindness Hemianopia Hemianopia, homonymous Quadrantanopia Stroke - occipital infarction Stroke, ischemic Vision loss partial Vision; loss, both eyes

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Rochester Medical Center

    RECRUITING

    Rochester, New York, 14642, United States

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