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POS-VAP: perpetual observational study - ventilator associated pneumonia

NCT ID NCT05719259

NEW Sponsor: European Clinical Research Alliance for Infectious Diseases (ECRAID) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 10, 2026

Summary

Ventilator-Associated Pneumonia (VAP) is a bacterial respiratory infection that patients in the Intensive Care Unit (ICU) often get when they cannot breathe for themselves and require mechanical ventilation. It is linked to higher chances of death, a longer stay in the hospital, higher costs, and the use of more antibiotics. Options to help prevent or treat this disease are in development and will require evaluation in future clinical trials. The goal of POS-VAP is to build and continuously train a network of ICUs to be prepared for doing these trials, to facilitate their execution.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2022

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients admitted to an ICU, who are under IMV and documented or expected to be under IMV for more than 48 hours are eligible to participate in the study

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Age≥18 years * At risk of acquiring VAP during ICU stay, defined as: * Requiring admission or being admitted to the ICU. * Expected or documented to be under IMV for more than 48 hours. * Consent, either a written informed consent given by the study patient in full medical, psychological, cognitive, social or legal capacity to give an informed consent, or, if not possible, by a Legally Authorized Representative of the study patient OR any applicable locally accepted form of consent OR consent waiver allowing data collection and sharing of data according to ECRAID's principles Exclusion Criteria: * Death is deemed to be imminent or inevitable during this hospital admission AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment.

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Conditions

The condition(s) this trial relates to.

nosocomial infection Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ventilator associated pneumonia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    33 sites in 13 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Central Military Emergency University Hospital Dr. Carol Davila

    RECRUITING

    Bucharest, Romania

  • Centre Hospitalier Régional Universitaire de Lille

    RECRUITING

    Lille, 59035, France

  • Centre Hospitalier Universitaire Dijon Bourgogne

    RECRUITING

    Dijon, 21079, France

  • Centre Hospitalier Universitaire Dupuytren of Limoges

    RECRUITING

    Limoges, 87000, France

  • Centre Hospitalier Universitaire de Liège

    NOT_YET_RECRUITING

    Liège, 4000, Belgium

  • Centre Hospitalier Universitaire de Tours

    RECRUITING

    Tours, 37000, France

  • Centre Hospitalier William Morey

    RECRUITING

    Chalon-sur-Saône, 71100, France

  • Centre Hospitalier de Le Mans

    RECRUITING

    Le Mans, 72000, France

  • Clinical Hospital Center Rijeka

    RECRUITING

    Rijeka, Croatia

  • Clinique Saint Pierre Ottignies

    ACTIVE_NOT_RECRUITING

    Ottignies-Louvain-la-Neuve, 1340, Belgium

  • Cliniques Universitaires Saint-Luc UCL

    RECRUITING

    Brussels, 1200, Belgium

  • Deventer Ziekenhuis

    RECRUITING

    Deventer, 7416, Netherlands

  • Elias University Emergency Hospital

    RECRUITING

    Bucharest, Romania

  • Evangelismos General Hospital of Athens

    NOT_YET_RECRUITING

    Athens, 10676, Greece

  • General Hospital "Dr. Josip Benčević" Slavonski Brod

    RECRUITING

    Slavonski Brod, Croatia

  • General University Hospital of Larissa

    NOT_YET_RECRUITING

    Larissa, 41334, Greece

  • Hospital Universitario Central de Asturias

    RECRUITING

    Oviedo, Principality of Asturias, 33011, Spain

  • Hospital Universitario Reina Sofia

    RECRUITING

    Córdoba, Cordoba, 14004, Spain

  • Hôpital de Jolimont

    RECRUITING

    La Louvière, 7100, Belgium

  • IMED Valencia

    RECRUITING

    Burjassot, Valencia, 46100, Spain

  • IRCCS Ospedale Policlinico Gemelli

    NOT_YET_RECRUITING

    Roma, Italy

  • John V Farman Intensive Care Unit

    NOT_YET_RECRUITING

    Cambridge, United Kingdom

  • Royal Infirmary of Edinburgh

    NOT_YET_RECRUITING

    Edinburgh, EH164SA, United Kingdom

  • Royal Victoria Infirmary

    NOT_YET_RECRUITING

    Newcastle, NE14LP, United Kingdom

  • Sotiria Thoracic Diseases Hospital of Athens

    NOT_YET_RECRUITING

    Athens, 11527, Greece

  • Universitair Ziekenhuis Gent

    RECRUITING

    Ghent, 9000, Belgium

  • University Clinical Center of Serbia

    RECRUITING

    Belgrade, 11000, Serbia

  • University Hospital Kralovske Vinohrady

    RECRUITING

    Brno-Vinohrady, Czechia

  • University Hospital Leipzig

    NOT_YET_RECRUITING

    Leipzig, 04103, Germany

  • University Hospital Motol

    RECRUITING

    Prague, Czechia

  • University Hospital for Infectious Diseases

    NOT_YET_RECRUITING

    Zagreb, Croatia

  • University Hospital of Alexandroupolis

    NOT_YET_RECRUITING

    Alexandroupoli, 68100, Greece

  • University Hospital of Trauma

    RECRUITING

    Tirana, Albania

  • University Medical Center Utrecht

    RECRUITING

    Utrecht, 3584, Netherlands

  • Vall d'Hebrón University Hospital

    ACTIVE_NOT_RECRUITING

    Barcelona, 08035, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.