Cure My Disease

Don't miss your cure!

 Log in / Sign up

Urine test may replace biopsies for kidney transplant patients

NCT ID NCT00337220

Diagnosis Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 25, 2026 · Last updated Sep 25, 2026

Summary

Researchers are studying whether analyzing urine samples for specific molecular markers can predict rejection in people who receive kidney transplants. The trial enrolls adults scheduled for kidney transplantation and follows them to see if the urine test matches biopsy results. The goal is to develop a noninvasive way to monitor transplant health and catch rejection early.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
urine test measuring mRNA markers
What this could lead to
If it works, this could give doctors a simple urine test to spot kidney transplant rejection early, reducing the need for invasive biopsies.
What could go wrong
The markers may not reliably predict rejection in all patients, and the test could miss cases or give false alarms. Larger studies are needed to confirm its accuracy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

492 people

The number who actually took part.

Start date

Jun 2006

Finished

Dec 2010

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who have recently undergone kidney transplant

Ages

Up to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled to undergo primary or redo deceased- or living-donor kidney transplantation * Ability to provide informed consent Exclusion Criteria: * Requires combined organ transplantation * Previously received a solid organ transplant (other than kidney transplant) or islet cell transplant * HCV infected * HIV infected

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Kidney disease are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome impaired renal function disease kidney disorder transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney disease Kidney failure, chronic Kidney transplantation

Contacts and locations

Locations

  • Columbia University

    New York, New York, 10032, United States

  • Cornell University

    New York, New York, 10021, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Wisconsin

    Madison, Wisconsin, 53792, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.