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Can simple tests replace biopsies for kidney transplant patients?

NCT ID NCT00308802

Diagnosis Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 25, 2026 · Last updated Sep 25, 2026

Summary

Researchers are testing noninvasive methods to monitor the health of newly transplanted kidneys in people who have received a kidney transplant. The study enrolls about 280 participants who are candidates for deceased or living donor kidney transplants. The goal is to see if these noninvasive tests can predict how well the kidney will function and detect problems early, potentially reducing the need for invasive biopsies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
noninvasive monitoring tests for kidney transplant recipients
What this could lead to
If these methods work, doctors could track kidney transplant health with simple tests instead of invasive biopsies, catching problems earlier and making follow-up care easier for patients.
What could go wrong
The study may find that noninvasive tests are not accurate enough to replace biopsies or predict outcomes reliably. Results from this group may not apply to all transplant recipients, and the monitoring approach could miss important changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

280 people

The number who actually took part.

Start date

Mar 2006

Finished

Jul 2011

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

People who are candidates for kidney transplant

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Candidate for deceased donor or living donor kidney transplant * Negative Crossmatch * Parent or guardian willing to provide informed consent, if applicable Exclusion Criteria: * Clinically significant liver disease * Other illnesses that, in the opinion of the investigator, may interfere with the study * Recipient of multiple organ transplants * Inability or unwillingness to comply with the study protocol

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Conditions

The condition(s) this trial relates to.

chronic kidney disease kidney disorder kidney failure Rejection, Psychology

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney transplantation

Contacts and locations

Locations

  • Children's Hospital of Winnipeg

    Winnipeg, Manitoba, R3A 151, Canada

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Emory Children's Center

    Atlanta, Georgia, 30322, United States

  • Emory University Hospital

    Atlanta, Georgia, 30322, United States

  • Mount Sinai School of Medicine

    New York, New York, 10029, United States

  • University Hospitals of Cleveland

    Cleveland, Ohio, 44195, United States

  • University of Manitoba

    Winnipeg, Manitoba, R3A 1R9, Canada

  • Yale University School of Medicine

    New Haven, Connecticut, 06510, United States

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