Researchers launch study to unravel mysteries of rare immune disorder sHLH

NCT ID NCT06339177

Recruiting now Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to understand why some adults develop secondary hemophagocytic lymphohistiocytosis (sHLH), a serious immune condition causing fevers and organ damage. Researchers will follow 300 participants for up to 3 years, collecting blood samples and medical data to identify immune patterns and triggers. No new treatments are given, but findings may lead to better diagnosis and future therapies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could point toward better diagnostic tools and potential targets for future treatments for secondary HLH.
What could go wrong: This is an observational study, not a treatment trial. It will not directly provide new therapies, and results may take years to translate into clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cytokine release syndrome hemophagocytic syndrome Hyperferritinemia juvenile idiopathic arthritis Lymphohistiocytosis, Hemophagocytic macrophage activation syndrome secondary hemophagocytic lymphohistiocytosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERINFLAMMATORY SYNDROMES LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC MACROPHAGE ACTIVATION SYNDROME SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15261, United States

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