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Ultrasound under the collarbone may help doctors decide who needs IV fluids after trauma

NCT ID NCT07817966

Diagnosis Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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The trial has finished. Results may not be published yet.
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Cancelled before anyone took part.

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When the status isn't known

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First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Severe bleeding after trauma can cause shock, and doctors often give IV fluids to stabilize patients. But only about half of unstable patients improve with fluids, and giving too much or too little can cause harm. This study compares two bedside ultrasound methods, one measuring the inferior vena cava in the abdomen and one measuring the subclavian vein under the collarbone, to see which better predicts whether a patient will benefit from fluids. Adult trauma patients with bleeding shock receive a standard fluid challenge while doctors track blood flow changes in the neck.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bedside ultrasound measurement of vein collapsibility
What this could lead to
If the subclavian vein method works as well as the standard inferior vena cava method, doctors could have an easier, more reliable way to decide which bleeding trauma patients need IV fluids.
What could go wrong
This is a single-center observational study of 120 patients, so the results may not apply to all hospitals or patient types. Ultrasound images can be hard to get in trauma patients, and the study does not test whether using either method actually improves patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult trauma patients aged 18 years or older presenting with blunt or penetrating trauma and clinical evidence of hemorrhagic shock (systolic blood pressure \< 90 mmHg, mean arterial pressure \< 65 mmHg, or clinical signs of tissue hypoperfusion) to the Emergency Department of Assiut University Trauma and Emergency Hospital within 6 hours of injury.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18 years or older. * Presentation with blunt or penetrating trauma. * Clinical evidence of hemorrhagic shock, defined by hypotension (systolic blood pressure \< 90 mmHg or mean arterial pressure \< 65 mmHg), tachycardia, or other clinical signs of tissue hypoperfusion requiring fluid resuscitation. * Spontaneously breathing patients. * Presentation to the Emergency Department within 6 hours of injury. * Feasibility of bedside point-of-care ultrasound examination prior to the initiation of definitive resuscitation. Exclusion Criteria: * Age younger than 18 years. * Pregnancy. * Requirement for immediate endotracheal intubation and mechanical ventilation prior to ultrasound assessment. * Obstructive shock due to cardiac tamponade, tension pneumothorax, or other known causes. * Known severe heart failure with left ventricular ejection fraction (LVEF) \< 40%. * Significant tricuspid regurgitation or known pulmonary hypertension that may affect systemic venous measurements. * Major neck or clavicular trauma preventing adequate subclavian vein ultrasound acquisition. * Extensive abdominal trauma, morbid obesity, or other conditions precluding adequate inferior vena cava (IVC) acoustic visualization. * Transfer from another facility after receiving large-volume fluid resuscitation (\> 1 L of crystalloids or blood products prior to assessment). * Inability or refusal to provide informed consent by the patient or their legally authorized representative.

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Conditions

The condition(s) this trial relates to.

Hypovolemia injury Shock, Hemorrhagic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fluid responsiveness Hemorrhagic shock Hypovolemia Trauma

How to take part

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  1. The official record

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