Umbilical cord stem cells could mend Worn-Out knees

NCT ID NCT06981741

Recruiting now Disease control Sponsor: BIONCaRT GmbH Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests whether stem cells from donated umbilical cord tissue can safely help repair damaged knee cartilage. Fifty-five adults with moderate to severe cartilage defects will receive the cells placed on a collagen patch during surgery. Researchers will track serious side effects for two years and use MRI scans to measure cartilage regrowth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: umbilical cord tissue stem cells (UC-MSC) placed on a collagen patch
What this could lead to: If it works, this could offer a new way to repair knee cartilage and reduce pain, potentially delaying or avoiding knee replacement.
What could go wrong: This is an early-phase trial with only 55 people, so results may not apply widely. Risks include surgery-related complications and the possibility that the stem cells do not improve cartilage healing.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARTILAGE DAMAGE

Contacts and locations

Locations

Evangelisches Waldkrankenhaus Spandau
RECRUITING

Berlin, 13589, Germany
GFO Kliniken Niederrhein, St. Vinzenz Hospital Dinslaken
RECRUITING

Dinslaken, 46535, Germany
Klinikum Altenburger Land, Klinik für Orthopädie und Unfallchirurgie
RECRUITING

Altenburg, 04600, Germany
Maria-Josef-Hospital Greven, Klinik für Unfallchirurgie und Orthopädie
RECRUITING

Greven, 48268, Germany
Sozialstiftung Bamberg Klinikum am Bruderwald, Klinik für Orthopädie und Unfallchirurgie
RECRUITING

Bamberg, 96049, Germany
St. Nikolaus Stifts-Hospital
RECRUITING

Andernach, 56626, Germany
UniversitätsCentrum für Orthopädie, Unfall- & Plastische Chirurgie, Universitätsklinikum Carl Gustav Carus an der TU Dresden
RECRUITING

Dresden, 01307, Germany

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