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Could a tubeless anesthesia technique protect the brain during lung surgery?

NCT ID NCT07721038

Knowledge-focused Sponsor: Guangzhou Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study looks at two ways to give anesthesia for chest surgery: one where patients breathe on their own without a breathing tube, and another using a standard double-lumen tube. Researchers want to see how each method affects sleep, pain, and thinking skills after surgery. By tracking 400 adults, they hope to build a safety system that supports brain recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
two anesthesia techniques: tubeless with preserved spontaneous breathing versus double-lumen endotracheal intubation
What this could lead to
If one technique proves better for brain health, it could guide safer anesthesia choices for thoracic surgery patients.
What could go wrong
This is an observational study, not a randomized trial, so results may show correlation, not causation. Individual patient factors could also influence outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who underwent elective non-anatomic partial lung resection surgery at the First Affiliated Hospital of Guangzhou Medical University

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient age: 18 - 75 years old * Patients meeting the standards of the American Society of Anesthesiologists (ASA) I-III grade and the New York Heart Association (NYHA) I-II class * Body Mass Index (BMI) \< 30 kg/m2 * Intraoperative blood loss less than 300 ml * No severe cardiac or pulmonary dysfunction \[first-second forced vital capacity (FEV1%) predicted value\] \> 50%, ejection fraction (EF) \> 50% * No contraindications related to paravertebral nerve block and intercostal nerve block * Able to sign the informed consent form and possess communication, reading and writing abilities * Postoperative hospital stay of at least one day * No preoperative sleep disorders, no cognitive dysfunction (PSQI ≤ 10 points, PCS ≤ 38 points, MMSE \> 27 points) Exclusion Criteria: * Already diagnosed with a mental disorder or had a preoperative Mini-Mental State Examination (MMSE) score of less than 27 * History of opioid abuse * Patients who were admitted to the ICU after surgery * Have severe cardiovascular, respiratory diseases * Experienced critical rescue during or after the surgery * Complicated with coagulation dysfunction, severe hypoxia or hypercapnia, or liver and kidney dysfunction * Difficult airway management * Changed anesthetic agent or surgical plan * Severe lacunar cerebral infarction, ischemic stroke or other neurological diseases * Changed anesthetic agent or surgical plan during the surgery;

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain health

How to take part

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  2. The official record

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Contacts and locations

Locations

  • the First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong, 510120, China

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