Brain fuel switch: can a ketone drink boost aging brains?

NCT ID NCT07711990

Recruiting now Knowledge-focused Sponsor: Christopher Crabtree Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study investigates whether a ketone ester supplement can alter brain function, blood flow, and metabolism in healthy adults aged 45 to 65. Ketones are an alternative fuel the body makes during fasting, and researchers want to see if raising ketone levels with a drink changes how the brain works. Participants will consume the supplement and a placebo on separate days, then undergo brain imaging, blood tests, and cognitive assessments. The goal is to understand how ketones influence the healthy aging brain and lay groundwork for future studies on cognitive decline.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a ketone ester drink
What this could lead to: If it works, this could point toward a way to support healthy brain aging through diet-like supplements.
What could go wrong: This is a small, early-stage study in healthy volunteers, so results may not apply to people with cognitive decline. The effects may be subtle or temporary.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN HEALTH

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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