New drug cocktail aims to boost remission in tough lymphoma
NCT ID NCT04803201
First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 5 times
Summary
This phase II trial tests whether adding either duvelisib or oral azacitidine to standard chemotherapy improves outcomes for people with certain types of peripheral T-cell lymphoma that have not been treated yet. About 170 participants will receive one of three treatment combinations. The main goal is to see which approach leads to more complete remissions, while also monitoring side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Duvelisib, oral azacitidine (CC-486), cyclophosphamide, doxorubicin, vincristine, etoposide, prednisone
- What this could lead to
- If successful, this could point toward a more effective first-line treatment for certain types of peripheral T-cell lymphoma, potentially improving remission rates.
- What could go wrong
- This is a phase II trial with only 170 participants, so results are preliminary. Adding new drugs to chemotherapy may increase side effects, and the study is currently suspended, which raises uncertainty.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AMG Libertyville - Oncology
Libertyville, Illinois, 60048, United States
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Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066, United States
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Augusta University Medical Center
Augusta, Georgia, 30912, United States
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Carle Cancer Center
Urbana, Illinois, 61801, United States
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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Cooper Hospital University Medical Center
Camden, New Jersey, 08103, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dartmouth Cancer Center - North
Saint Johnsbury, Vermont, 05819, United States
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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756, United States
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Dayton Physician LLC - Englewood
Dayton, Ohio, 45415, United States
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Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015, United States
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Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342, United States
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Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Essentia Health Cancer Center
Duluth, Minnesota, 55805, United States
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Grady Health System
Atlanta, Georgia, 30303, United States
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Grant Medical Center
Columbus, Ohio, 43215, United States
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Greater Dayton Cancer Center
Kettering, Ohio, 45409, United States
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Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
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Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548, United States
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Marshfield Medical Center - Weston
Weston, Wisconsin, 54476, United States
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Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701, United States
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Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449, United States
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Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868, United States
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Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Memorial Hospital East
Shiloh, Illinois, 62269, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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Mercy Hospital Springfield
Springfield, Missouri, 65804, United States
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Miami Valley Cancer Care and Infusion
Greenville, Ohio, 45331, United States
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Miami Valley Hospital
Dayton, Ohio, 45409, United States
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Miami Valley Hospital North
Dayton, Ohio, 45415, United States
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Miami Valley Hospital South
Centerville, Ohio, 45459, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
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NYP/Weill Cornell Medical Center
New York, New York, 10065, United States
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Nebraska Medicine-Bellevue
Bellevue, Nebraska, 68123, United States
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Nebraska Medicine-Village Pointe
Omaha, Nebraska, 68118, United States
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Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134, United States
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Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115, United States
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Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555, United States
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Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Our Lady of the Lake Physician Group
Baton Rouge, Louisiana, 70808, United States
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Premier Blood and Cancer Center
Dayton, Ohio, 45409, United States
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Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362, United States
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Rhode Island Hospital
Providence, Rhode Island, 02903, United States
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Riverside Methodist Hospital
Columbus, Ohio, 43214, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Saint Luke's Hospital
Chesterfield, Missouri, 63017, United States
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Siteman Cancer Center at Christian Hospital
St Louis, Missouri, 63136, United States
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Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141, United States
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Siteman Cancer Center-South County
St Louis, Missouri, 63129, United States
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Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114, United States
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, 50023, United States
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UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309, United States
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UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, 50314, United States
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UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa, 50263, United States
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
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University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
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University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219, United States
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University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, 45069, United States
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University of Illinois
Chicago, Illinois, 60612, United States
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University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242, United States
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University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210, United States
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University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205, United States
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University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
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University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States
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University of Rochester
Rochester, New York, 14642, United States
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University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
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University of Washington Medical Center - Montlake
Seattle, Washington, 98195, United States
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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, 53718, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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Upper Valley Medical Center
Troy, Ohio, 45373, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Wilmot Cancer Institute at Webster
Webster, New York, 14580, United States
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