Sleep drug trazodone tested to boost memory in Alzheimer's

NCT ID NCT05282550

Recruiting now Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether trazodone, a sleep medication, can improve sleep and memory in people with early Alzheimer's and sleep problems. About 100 participants will receive either trazodone or a placebo for 4 weeks. Researchers will measure changes in sleep quality and memory performance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: trazodone
What this could lead to: If it works, this could point toward a simple way to improve sleep and possibly slow memory decline in early Alzheimer's.
What could go wrong: This is a small, early-phase trial. Trazodone may not improve sleep or memory significantly, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Parasomnias sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMCI - AMNESTIC MILD COGNITIVE IMPAIRMENT SLEEP DISTURBANCE

Contacts and locations

Locations

Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21205, United States

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