Promising combo trial for aggressive breast cancer halted early

NCT ID NCT05583110

First seen Jan 04, 2026 · Last updated May 16, 2026 · Updated 23 times

Summary

This study tested a combination of three drugs—trastuzumab, tucatinib, and vinorelbine—in people with HER2-positive breast cancer that had spread or could not be removed by surgery. The goal was to see how well the treatment shrank tumors and how safe it was. Only 13 people enrolled before the study was stopped early, so results are limited.

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Contacts and locations

Locations

  • Complejo hospitalario Universitario Insular-Materno Infantil

    Las Palmas de Gran Canaria, Las Palmas, 35016, Spain

  • Hospital Clínico Universitario Lozano Blesa

    Zaragoza, Aragon, 50009, Spain

  • Hospital Clínico Universitario de Valladolid

    Valladolid, Castille and León, 47003, Spain

  • Hospital Costa del Sol

    Málaga, Andalusia, 29603, Spain

  • Hospital General Universitario Gregorio Marañón

    Madrid, 28009, Spain

  • Hospital Nuestra Señora de Sonsoles

    Ávila, Castille and León, 05004, Spain

  • Hospital San Juan de Alicante

    Alicante, Valencia, 03550, Spain

  • Hospital Universitario Central de Asturias

    Oviedo, Principality of Asturias, 33011, Spain

  • Hospital Universitario Donostia

    Donostia / San Sebastian, Basque Country, 20014, Spain

  • Hospital Universitario Quironsalud Madrid

    Madrid, 28223, Spain

  • Hospital Universitario Reina Sofía

    Córdoba, Andalusia, 14004, Spain

  • Hospital Universitario Virgen de Valme

    Seville, Andalusia, 41014, Spain

  • Hospital Universitario de Araba

    Vitoria-Gasteiz, Álava, 01009, Spain

  • Hospital Universitario de Bádajoz

    Bádajoz, Extremadura, 06080, Spain

  • Hospital Universitario de Jaén

    Jaén, Andalusia, 23007, Spain

  • Hospital Universitario de Jeréz De La Frontera

    Cadiz, Andalusia, 11407, Spain

  • Hospital Álvaro Cunqueiro

    Vigo, Galicia, 36213, Spain

  • ICO Badalona

    Barcelona, Catalonia, 08916, Spain

Conditions

Explore the condition pages connected to this study.