Can a cheap clot drug save lives in blood cancer patients?

NCT ID NCT03136445

Completed Disease control Sponsor: NHS Blood and Transplant Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the risk of serious bleeding or death in people with blood cancers who have dangerously low platelet counts. Over 600 adults receiving chemotherapy or a stem cell transplant were randomly given either the drug or a placebo. The goal was to see if the drug could reduce the need for platelet transfusions and improve outcomes during the first 30 days of treatment.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOLOGIC NEOPLASMS HEMATOPOIETIC STEM CELL TRANSPLANTATION HEMORRHAGE

Contacts and locations

Locations

Alfred Hospital

Melbourne, Australia
Andrew Love Cancer Centre

Geelong, Australia
Beatson West of Scotland Cancer Centre

Glasgow, United Kingdom
Belfast City Hospital

Belfast, United Kingdom
Bristol Haematology and Oncology Centre

Bristol, United Kingdom
Canberra Hospital

Canberra, Australia
Churchill Hospital

Oxford, United Kingdom
Derriford Hospital

Plymouth, United Kingdom
Freeman Hospital

Newcastle, United Kingdom
Heartlands Hospital

Birmingham, United Kingdom
King's College Hospital

London, United Kingdom
Lincoln County Hospital

Lincoln, United Kingdom
Monash Health

Melbourne, Australia
Queen Elizabeth Hospital

Birmingham, United Kingdom
Royal Adelaide Hospital

Adelaide, Australia
Royal Brisbane

Brisbane, Australia
Royal Devon and Exeter Hospital

Exeter, United Kingdom
Royal North Shore Hospital

St Leonards, Australia
Royal United Hospital

Bath, United Kingdom
Salisbury District Hospital

Salisbury, United Kingdom
St James's Hospital

Leeds, United Kingdom
St Vincent's Hospital

Melbourne, Australia
St Vincent's Hospital

Sydney, Australia
University College London Hospitals

London, United Kingdom
University Hospital Coventry

Coventry, United Kingdom
Victorian Comprehensive Cancer Centre

Melbourne, Australia
Westmead Hospital

Westmead, Australia

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