Could a cream replace surgery for pilonidal disease?
NCT ID NCT06286397
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a cream called clascoterone on people with pilonidal disease, a skin condition in the buttock crease. For 12 weeks, participants apply the cream or a placebo twice daily. Researchers check if the cream improves disease severity and symptoms. The trial involves 75 adults and is run by the University of Pennsylvania.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- clascoterone cream
- What this could lead to
- If it works, this could offer a non-surgical treatment option for pilonidal disease, reducing pain and inflammation.
- What could go wrong
- This is an early phase 2 trial with only 75 people. It may not show significant improvement over placebo, and results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19103, United States
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