Could a cream replace surgery for pilonidal disease?
NCT ID NCT06286397
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a cream called clascoterone on people with pilonidal disease, a skin condition in the buttock crease. For 12 weeks, participants apply the cream or a placebo twice daily. Researchers check if the cream improves disease severity and symptoms. The trial involves 75 adults and is run by the University of Pennsylvania.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
clascoterone cream
What this could lead to
If it works, this could offer a non-surgical treatment option for pilonidal disease, reducing pain and inflammation.
What could go wrong
This is an early phase 2 trial with only 75 people. It may not show significant improvement over placebo, and results may not apply to everyone.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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