New spray device could replace needles for throat numbing during endoscopy
NCT ID NCT07563062
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new device that numbs the throat and esophagus (OPETA) against standard IV sedation with propofol and ketamine for upper GI endoscopy. 60 adults were enrolled to see which method causes less discomfort and has fewer side effects. The goal is to find a safer, more comfortable option for patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Propofol and Ketamine mixture (Ketofol)
What this could lead to
If successful, this could offer a safer, needle-free alternative to IV sedation for upper GI endoscopy, reducing risks like breathing problems.
What could go wrong
This is a small, completed trial with only 60 participants. The new device may not be as effective or comfortable as IV sedation for all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Zagazig university hospitals
Zagazig, Sharqia Province, 44111, Egypt