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Cancer Patients' chest fluid: can a Clot-Buster help drain it?

NCT ID NCT01580618

Terminated Disease control Sponsor: Kaiser Permanente Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a drug called TNK (tenecteplase) could help drain loculated (pocketed) fluid from the chest in cancer patients better than a saltwater solution. The trial planned to enroll about 20 adults with cancer and a chest tube already in place. However, the study was terminated early, so the findings are limited and not conclusive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Tenecteplase (TNK)
What this could lead to
If it works, this could offer a way to better drain fluid pockets in the chest for cancer patients, potentially reducing discomfort and the need for more invasive procedures.
What could go wrong
The trial was terminated early and enrolled only 20 people, so results are very limited. TNK can also increase the risk of bleeding complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm Pleural Effusion

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLEURAL EFFUSION

Contacts and locations

Locations

  • Kaiser Foundation Hospital

    Honolulu, Hawaii, 96819, United States

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