Bacterial wall chemical injected into tumors shows promise in early safety trial
NCT ID NCT05751837
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early study tested whether a sterile bacterial chemical called lipopolysaccharide (LPS) can be safely injected into abdominal tumors during laparoscopic surgery. Twelve adults with advanced digestive tract tumors received one injection into a tumor, and researchers checked for side effects and immune changes. The goal was to see if the treatment is safe and can activate the immune system against the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Lipopolysaccharide (LPS), a bacterial wall chemical
- What this could lead to
- If safe, this could point toward a new way to stimulate the immune system to fight abdominal tumors during surgery.
- What could go wrong
- This is a very early Phase 1 trial with only 12 people, focused on safety, not effectiveness. The treatment may not shrink tumors or improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Allegheny Health Network Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
-
Allegheny Health Network West Penn Hospital
Pittsburgh, Pennsylvania, 15224, United States
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