Blood test may foretell Radiation's toll on the gut

NCT ID NCT07759258

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This observational study is investigating whether a blood marker called GLP-2 could help predict the risk and severity of acute radiation enteritis—a common and painful side effect of radiation therapy to the abdomen or pelvis. Researchers will measure GLP-2 levels in 50 adults before, at the end of, and one month after their standard radiotherapy, and track who develops gut inflammation. The goal is to see if changes in GLP-2 are linked to intestinal injury, inflammation, and quality of life, potentially paving the way for a simple blood test to guide care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Abdominopelvic radiotherapy (standard of care, not modified by the study)
What this could lead to
If GLP-2 levels correlate with radiation enteritis, it could become a simple blood test to identify patients at higher risk, enabling earlier intervention or treatment adjustments.
What could go wrong
This is a small observational study, so it can only show associations, not cause and effect. The results may not apply to all patients or lead to a proven clinical test.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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