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Real-time hormone and nerve checks during thyroid surgery could flag complications before they appear

NCT ID NCT03309384

Diagnosis Sponsor: Central Hospital, Nancy, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 20, 2026 · Last updated Oct 21, 2026 · Updated 1 time

Summary

Researchers are studying whether measuring parathyroid hormone levels and monitoring laryngeal nerves during total thyroidectomy can predict which patients will develop low calcium or nerve injury afterward. The trial enrolls about 1,000 adults scheduled for total thyroid removal at a university hospital in Nancy, France. During surgery, the team records continuous and intermittent nerve signals and parathyroid hormone values, then tracks postoperative calcium, hormone levels, and vocal cord function to see how well those intraoperative readings forecast complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intraoperative continuous and intermittent neuromonitoring and parathyroid hormone measurement
What this could lead to
If it works, surgeons could use real-time hormone levels and nerve signals to flag patients at risk of low calcium or vocal cord nerve injury right after thyroid removal, allowing earlier treatment.
What could go wrong
This is an observational prediction study, not a treatment trial. The monitoring may not reliably forecast complications, and the findings may not apply to hospitals with different surgical techniques.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Mar 2016

Finished

Oct 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients scheduled for total thyroidectomy in university of Nancy (University Hospital)

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients scheduled for total thyroidectomy in university of Nancy (University Hospital) Exclusion Criteria: * refusal to participate

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Conditions

The condition(s) this trial relates to.

hypoparathyroidism thyroid gland disorder thyroid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endocrine procedural complications Laryngeal injury Parathyroid; deficiency Thyroid

Contacts and locations

Locations

  • CHU Nancy

    Vandœuvre-lès-Nancy, 54511, France

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