Third MMR dose may revive waning immunity in adults

NCT ID NCT05923970

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looks at whether a third dose of the MMR vaccine can improve immunity in adults whose antibody levels have dropped below protective levels. Researchers will measure immune responses in 200 women who already received a third dose through routine care. The goal is to understand if an extra shot helps maintain protection against measles, mumps, rubella, and varicella.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

What this could lead to
If successful, this could show that a third MMR dose helps restore protection in adults whose immunity has faded over time.
What could go wrong
This is a small observational study (200 participants) that does not give the vaccine itself. Results may not apply to everyone, and it only measures immune markers, not actual infection prevention.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Alberta

    RECRUITING

    Edmonton, Alberta, T6G2R3, Canada

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