New combo therapy targets liver cancer in clinical trial
NCT ID NCT05063565
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This study tests a two-step treatment for liver cancer. First, patients receive TheraSphere, tiny radioactive beads injected into the liver to target tumors. Then, they get two immunotherapy drugs (durvalumab and tremelimumab) to help the immune system fight remaining cancer cells. The goal is to see if this combination shrinks tumors and is safe for about 100 adults with liver cancer.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Azienda Sanitaria Universitaria Integrata Friuli Centrale (ASU FC)
Udine, Italy
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CHU Angers - Hôpital Hôtel Dieu
Nantes, 49033, France
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CHU Grenoble
Grenoble, Isere, 38043, France
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CHU Montpellier
Montpellier, 34295, France
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CHU Nantes
Rennes, Cedex, 35042, France
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CHU de Bordeaux - Hôpital Haut-Lévêque
Clermont-Ferrand, France
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CRLCC Eugene Marquis
Rennes, France
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Chru De Lille
Lille, 59037, France
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Chu Henri Mondor
Créteil, 94010, France
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Clinica Universidad de Navarra
Pamplona, Navarre, 31008, Spain
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Clinico de Valladolid
Valladolid, 47012, Spain
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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Georgetown University
Washington D.C., District of Columbia, 20007, United States
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Hopital Paul Brousse
Villejuif, 94800, France
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Hospital Clinic de Barcelona
Barcelona, Catalonia, 08036, Spain
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Hospital Gregorio Maranon
Madrid, Spain
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Hospital Universitari
Valencia, 46026, Spain
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Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, 33006, Spain
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Hospital Universitario Virgen de las Nieves
Madrid, Spain
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Hospital. Ramon Y Cajal
Madrid, Spain
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Hôpital Beaujon
Clichy, Hauts De Seine, 92110, France
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IRCCS - Regina Elena Cancer Institute
Roma, Italy
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Intermountain Health
Salt Lake City, Utah, 84157, United States
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Mayo Clinic
Jacksonville, Florida, 32224, United States
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MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
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National Cancer Institute of Milan, Italy
Milan, 20133, Italy
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Ochsner Clinic Foundation
New Orleans, Louisiana, 70121, United States
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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University Hospital Geneva (HUG)
Geneva, 1211, Switzerland
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University Hospital of Bern
Bern, 3010, Switzerland
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University of Arizona- Banner Health
Tucson, Arizona, 85724, United States
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University of California San Diego
San Diego, California, 92093, United States
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Chicago Hospital
Chicago, Illinois, 60637, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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Washington University (Barnes-Jewish Hospital)
St Louis, Missouri, 63101, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a simple scan and blood test outsmart liver cancer?
- Could a vaccine help fight Hard-to-Treat cancers?
- Could a tailored diet before surgery boost liver cancer recovery?
- Can a new PET tracer light up hidden cancers?
- A new test could reveal how radiation affects the liver
- Can an immunotherapy drug keep liver cancer at bay after surgery?