Could thalidomide and glutamine heal Radiation-Damaged intestines?
NCT ID NCT06617182
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether thalidomide combined with glutamine can reduce bleeding in people with chronic radiation injury to the intestines. 150 adults who have rectal bleeding after past radiation therapy will take one or both drugs for 8 weeks. The goal is to see if the combination works better than either drug alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
thalidomide and glutamine
What this could lead to
If successful, this could offer a new treatment option for people with chronic radiation damage to the gut, reducing bleeding and improving quality of life.
What could go wrong
This is a small, early-phase trial (phase 2) with no placebo group, so results may not be definitive. Thalidomide has known side effects like drowsiness and nerve damage.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Department of Gastroenterology & Hepatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Ch
RECRUITINGXi'an, Shaanxi, 710005, China
Contact Phone: •••-•••-•••• Email: •••••@•••••