Could thalidomide and glutamine heal Radiation-Damaged intestines?
NCT ID NCT06617182
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether thalidomide combined with glutamine can reduce bleeding in people with chronic radiation injury to the intestines. 150 adults who have rectal bleeding after past radiation therapy will take one or both drugs for 8 weeks. The goal is to see if the combination works better than either drug alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- thalidomide and glutamine
- What this could lead to
- If successful, this could offer a new treatment option for people with chronic radiation damage to the gut, reducing bleeding and improving quality of life.
- What could go wrong
- This is a small, early-phase trial (phase 2) with no placebo group, so results may not be definitive. Thalidomide has known side effects like drowsiness and nerve damage.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Department of Gastroenterology & Hepatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Ch
RECRUITINGXi'an, Shaanxi, 710005, China
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