Boosting CAR t cells: could a pill make lymphoma therapy more effective?
NCT ID NCT05934838
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial explores whether adding the drug tazemetostat (Tazverik) to standard CAR T cell therapy can help the immune cells better recognize and destroy lymphoma cells. It enrolls people with diffuse large B-cell lymphoma, follicular lymphoma, or mantle cell lymphoma who have already tried at least one prior treatment. Participants take tazemetostat pills before and after receiving their CAR T cells, continuing for up to a year, and are monitored for side effects and response for up to five years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tazemetostat (Tazverik) plus CAR T cells
What this could lead to
If successful, this combination could make CAR T therapy more effective at killing lymphoma cells, potentially improving long-term control of the disease.
What could go wrong
This is a small, early-phase feasibility study, so results may not apply broadly. Adding tazemetostat could increase side effects like cytokine release syndrome or immune-related neurotoxicity.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Weill Cornell Medicine/NewYork-Presbyterian Hospital
New York, New York, 10065, United States