Personalized chemo shows promise against rare sarcomas

NCT ID NCT01710176

Completed Disease control Sponsor: Italian Sarcoma Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tested whether giving chemotherapy based on the specific type of soft tissue sarcoma works better than a one-size-fits-all approach. 550 adults with high-risk sarcomas in the arms or trunk were randomly assigned to standard chemo or a chemo regimen matched to their tumor type. The main goal was to see if the tailored approach improves disease-free survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: chemotherapy drugs (epirubicin, ifosfamide, gemcitabine, docetaxel, trabectedin, etoposide, dacarbazine)
What this could lead to: If successful, this could show that matching chemotherapy to the specific sarcoma subtype improves the chance of keeping the cancer from coming back.
What could go wrong: This is a completed Phase 3 trial, but results are not yet widely confirmed. The benefit may vary by sarcoma subtype, and chemotherapy has significant side effects.

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Conditions

The condition(s) this trial relates to.

leiomyosarcoma malignant peripheral nerve sheath tumor myxofibrosarcoma myxoid/round cell liposarcoma pleomorphic liposarcoma pleomorphic rhabdomyosarcoma soft tissue sarcoma spindle cell sarcoma synovial sarcoma undifferentiated pleomorphic sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED HIGH-RISK SOFT TISSUE SARCOMAS OF THE EXTREMITIES AND TRUNK WALL IN ADULTS

Contacts and locations

Locations

Fondazione Del Piemonte Per L'Oncologia Ircc Di Candiolo -

Candiolo, TO, Italy
Hospital Clínico de Malaga

Málaga, Spain
Hospital Son Espases

Palma de Mallorca, Spain
Hospital Vall D'Hebron

Barcelona, Spain
Irccs Centro Di Riferimento Oncologico (Cro) -

Aviano (PN), Italy
Irccs Istituto Clinico Humanitas -

Rozzano (MI), Italy
Irccs Istituto Europeo Di Oncologia (Ieo) -

Milan, Italy
Irccs Istituto Nazionale Dei Tumori (Int)

Milan, Italy
Irccs Istituto Nazionale Tumori Fondazione Pascale -

Naples, Italy
Irccs Istituto Oncologico Veneto (Iov)

Padova, Italy
Irccs Istituto Ortopedico Rizzoli (Ior) -

Bologna, Italy
Irccs Istituto Regina Elena (Ifo)

Roma, Italy
Irst - Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori -

Meldola (FC), Italy
Pres.Ospedal.Spedali Civili Brescia -

Brescia, Italy
Presidio Sanitario Gradenigo Di Torino

Torino, Italy

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