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Personalized chemo shows promise against rare sarcomas

NCT ID NCT01710176

Completed Disease control Sponsor: Italian Sarcoma Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tested whether giving chemotherapy based on the specific type of soft tissue sarcoma works better than a one-size-fits-all approach. 550 adults with high-risk sarcomas in the arms or trunk were randomly assigned to standard chemo or a chemo regimen matched to their tumor type. The main goal was to see if the tailored approach improves disease-free survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

chemotherapy drugs (epirubicin, ifosfamide, gemcitabine, docetaxel, trabectedin, etoposide, dacarbazine)

What this could lead to

If successful, this could show that matching chemotherapy to the specific sarcoma subtype improves the chance of keeping the cancer from coming back.

What could go wrong

This is a completed Phase 3 trial, but results are not yet widely confirmed. The benefit may vary by sarcoma subtype, and chemotherapy has significant side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

leiomyosarcoma malignant peripheral nerve sheath tumor myxofibrosarcoma myxoid/round cell liposarcoma pleomorphic liposarcoma pleomorphic rhabdomyosarcoma soft tissue sarcoma spindle cell sarcoma synovial sarcoma undifferentiated pleomorphic sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED HIGH-RISK SOFT TISSUE SARCOMAS OF THE EXTREMITIES AND TRUNK WALL IN ADULTS

Contacts and locations

Locations

  • Fondazione Del Piemonte Per L'Oncologia Ircc Di Candiolo -

    Candiolo, TO, Italy

  • Hospital Clínico de Malaga

    Málaga, Spain

  • Hospital Son Espases

    Palma de Mallorca, Spain

  • Hospital Vall D'Hebron

    Barcelona, Spain

  • Irccs Centro Di Riferimento Oncologico (Cro) -

    Aviano (PN), Italy

  • Irccs Istituto Clinico Humanitas -

    Rozzano (MI), Italy

  • Irccs Istituto Europeo Di Oncologia (Ieo) -

    Milan, Italy

  • Irccs Istituto Nazionale Dei Tumori (Int)

    Milan, Italy

  • Irccs Istituto Nazionale Tumori Fondazione Pascale -

    Naples, Italy

  • Irccs Istituto Oncologico Veneto (Iov)

    Padova, Italy

  • Irccs Istituto Ortopedico Rizzoli (Ior) -

    Bologna, Italy

  • Irccs Istituto Regina Elena (Ifo)

    Roma, Italy

  • Irst - Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori -

    Meldola (FC), Italy

  • Pres.Ospedal.Spedali Civili Brescia -

    Brescia, Italy

  • Presidio Sanitario Gradenigo Di Torino

    Torino, Italy