First-in-Human trial launches: reprogrammed immune cells hunt deadly cancer mutations

NCT ID NCT06218914

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This early-stage study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific genetic change called KRAS G12D. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recognize and attack cancer cells with this mutation, and then infuse them back into the patient. The main goals are to find a safe dose and see if this approach shows any early signs of shrinking tumors in cancers like lung, colorectal, and pancreatic cancer that have stopped responding to standard treatments.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Research Site
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Duarte, California, 91010, United States
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Los Angeles, California, 90095, United States
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Newport Beach, California, 92663, United States
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Jacksonville, Florida, 32224, United States
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Chicago, Illinois, 60637, United States
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Westwood, Kansas, 66205, United States
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Boston, Massachusetts, 02115, United States
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St Louis, Missouri, 63110, United States
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New York, New York, 10016, United States
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NOT_YET_RECRUITING

New York, New York, 10065, United States
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Philadelphia, Pennsylvania, 19107, United States
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Pittsburgh, Pennsylvania, 15237, United States
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Nashville, Tennessee, 37203, United States
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Dallas, Texas, 75246, United States
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Galveston, Texas, 77555, United States
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Houston, Texas, 77030, United States
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Aberdeen, Washington, 98520, United States
Research Site
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Milwaukee, Wisconsin, 53226, United States

Conditions

Explore the condition pages connected to this study.

COLORECTAL CARCINOMA ENDOMETRIAL CANCER KRAS G12D NON SMALL CELL LUNG CANCER PANCREATIC DUCTAL ADENOCARCINOMA SOLID TUMOR, ADULT