Radioactive drug trial for advanced cancers halted early

NCT ID NCT03746431

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 29 times

Summary

This study tested a new radioactive drug, [225Ac]-FPI-1434, in people with advanced solid tumors that had stopped responding to standard treatments. The goal was to check safety and find the right dose. The study was terminated early, so results are limited. It involved 78 participants with various cancers like breast, ovarian, and head and neck cancer.

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Contacts and locations

Locations

  • Austin Hospital

    Heidelberg, Victoria, 3084, Australia

  • Centre Hospitalier De I'Universite de Montreal

    Montreal, Quebec, H2X 0C1, Canada

  • City of Hope

    Duarte, California, 91010, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Juravinski Cancer Center - Hamilton Health

    Hamilton, Ontario, L8V 5C2, Canada

  • Masonic Cancer Center, University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2C1, Canada

  • Quebec University Hospital- Laval

    Québec, Quebec, G1R 2J6, Canada

  • Roswell Park Comprehensive Cancer Center

    Buffalo, New York, 14203, United States

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.