Which pill best calms stent pain? new study pits four drugs against placebo

NCT ID NCT07447518

Completed Symptom relief Sponsor: Kafrelsheikh University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed early-phase trial tested four drugs (mirabegron, tamsulosin, solifenacin, and tadalafil) against a placebo to see which best relieves lower urinary tract symptoms caused by double-J stents. Over 500 adults who needed a stent after ureteroscopy or kidney stone surgery took one pill daily. The main goal was to measure symptom improvement using a standard questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mirabegron, tamsulosin, solifenacin, tadalafil
What this could lead to: If successful, this could identify which drug best reduces discomfort and urinary problems from ureteral stents, improving patient quality of life.
What could go wrong: This is an early-phase trial with a placebo group, so results may not show a clear winner or may have modest benefits. Side effects from the drugs are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Lower Urinary Tract Symptoms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOWER URINARY TRACT SYMPTOMS

Contacts and locations

Locations

Elsayed Abdelhalim

Zagazig, 44749, Egypt

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