Stem cells injected into gut to fight Crohn's – but trial stops early
NCT ID NCT04548583
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tested whether injecting donor stem cells directly into the colon could help people with severe Crohn's colitis that didn't respond to standard treatments. Only 7 people took part before the study was stopped early. The main goal was to check safety, but because it was so small and unfinished, we can't draw firm conclusions about how well it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Remestemcel-L (stem cells from a donor's bone marrow)
- What this could lead to
- If it works, this could point toward a new way to treat severe Crohn's colitis without surgery.
- What could go wrong
- This was a very small, early-phase trial that was terminated early, so we don't know if it's safe or effective. Stem cell treatments can have unknown long-term risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cleveland Clinic
Cleveland, Ohio, 44195, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.